Indications And Dose
Cushing’s disease [when surgery has failed or is inappropriate] ▶BY SUBCUTANEOUS INJECTION ▶Adult: Initially 600 micrograms twice daily for 2 months, then increased if necessary to 900 micrograms twice daily, consider discontinuation if no response after 2 months of treatment, for dose adjustment due to side-effects—consult product literature ▶BY DEEP INTRAMUSCULAR INJECTION ▶Adult: Initially 10 mg every 4 weeks, increased if necessary up to 40 mg every 4 weeks, dose may be titrated every 2–4 months based on response and tolerability, consider discontinuation if no clinical benefit observed, for dose adjustment due to side- effects—consult product literature Acromegaly [when surgery has failed or is inappropriate, and control with another somatostatin analogue is inadequate] ▶BY DEEP INTRAMUSCULAR INJECTION ▶Adult: Initially 40 mg every 4 weeks, increased if necessary up to 60 mg every 4 weeks, dose may be increased if levels of growth hormone and/or insulin- like growth factor-1 are not fully controlled after 3 months of initial dosing, for dose adjustment due to side-effects—consult product literature
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