Names and pronunciation
(pat-i-sir′an) Onpattro
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Drug reference
(pat-i-sir′an) Onpattro
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Func. class.: Metabolic agent, P anti-transthyretin small interfering ribonucleic acid (siRNA) agent
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USES: Treatment of the polyneuropa- thy of hereditary transthyretin-mediated amyloidosis in adults
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CONTRAINDICATIONS Hypersensitivity
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DOSAGE AND ROUTES At least 1 hr before use, premedicate with a corticosteroid, acetaminophen, an H1 blocker, and an H2 blocker to reduce the risk of infusion-related reactions (IRR) • Adult: IV: Base dose on actual body weight; <100 kg: 0.3 mg/kg once q3wk; ≥100 kg: 30 mg once q3wk
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Available forms: Injection 2 mg/mL in 5-mL single-dose vials HIGH ALERT
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• Adult: IV: Base dose on actual body weight; <100 kg: 0.3 mg/kg once q3wk; ≥100 kg: 30 mg once q3wk
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