Indications And Dose
Hairy cell leukaemia (initiated in specialist centres) ▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: To be given on alternate weeks (consult product literature)
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Drug reference
Hairy cell leukaemia (initiated in specialist centres) ▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: To be given on alternate weeks (consult product literature)
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→Appendix 1: pentostatin
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▶Common or very common Agranulocytosis. alopecia. amenorrhoea. anaemia. angina pectoris. anxiety. appetite decreased. arrhythmias. arthritis. asthenia. asthma. atrioventricular block. blood disorder. bone disorder. bone marrow disorders. breast mass. cardiac arrest. chest pain. chills. confusion. constipation. cough. deafness. death. depersonalisation. depression. diarrhoea. dizziness. drowsiness. dry eye. dry mouth. dysarthria. dysphagia. dyspnoea. ear pain. electrolyte imbalance. embolism and thrombosis. emotional lability. eosinophilia. eye disorders. eye inflammation. eye pain. febrile neutropenia. fever. fluid imbalance. flushing. gastrointestinal discomfort. gastrointestinal disorders. gout. graft versus host disease. haemorrhage. hallucination. hangover. headaches. heart failure. hostility. hyperbilirubinaemia. hyperglycaemia. hyperhidrosis. hypersensitivity. hypertension. hypotension. increased risk of infection. influenza like illness. jaundice. joint disorders. leucopenia. lymphadenopathy. malaise. memory loss. meningism. movement disorders. muscle complaints. nausea. neoplasms. nephrolithiasis. nephropathy. nerve disorders . neurotoxicity (withhold or discontinue). oedema. oral disorders. pain. paralysis. pericardial effusion. photosensitivity reaction. pulmonary oedema. rash (withhold if severe). renal impairment. respiratory disorders. retinopathy. seborrhoea. seizures. sensation abnormal. sepsis. sexual dysfunction. skin reactions. sleep disorders. splenomegaly. syncope. taste altered. thinking abnormal. thrombocytopenia. tinnitus. tremor. urinary disorders. urogenital disorder. vasculitis. vertigo. vision disorders. vomiting. weight changes ▶Uncommon Angioedema. antibiotic associated colitis. capillary leak syndrome. cardiomyopathy. cystitis. haemolytic anaemia. mucositis. multi organ failure. myocardial infarction. pure red cell aplasia. transplant failure. tumour lysis syndrome ▶Rare or very rare Dementia. pericarditis. shock. Stevens- Johnson syndrome. systemic inflammatory response syndrome SIDE-EFFECTS, FURTHER INFORMATION Pentostatin can cause myelosuppression, immunosuppression, and a number of other side-effects that may be severe. Treatment should be withheld in patients who develop a severe rash, and withheld or discontinued in patients showing signs of neurotoxicity.
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Manufacturer advises that men should not father children during and for 6 months after treatment.
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Avoid (teratogenic in animal studies). See also Pregnancy and reproductive function in Cytotoxic drugs p. 938. Immune system and malignant disease
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Discontinue breast-feeding.
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Manufacturer advises caution (limited information available).
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Avoid if creatinine clearance less than 60 mL/minute.
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There can be variation in the licensing of different medicines containing the same drug. Powder for solution for injection ▶Nipent (Pfizer Ltd) Pentostatin 10 mg Nipent 10mg powder for solution for injection vials | 1 vial P £734.21 (Hospital only) ANTINEOPLASTIC DRUGS › PLANT ALKALOIDS
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To be given on alternate weeks (consult product
First-line fragment. Read the complete Indications and Dose section above.
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