Drug reference
Peripheral vascular disease | Venous leg ulcer (adjunct) ▶BY MOUTH ▶Adult: 400 mg 2–3 times a day l UNLICENSED USE Use of pentoxifylline as adjunct therapy for venous leg ulcers is an unlicensed indication.
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Acute myocardial infarction. cerebral haemorrhage. extensive retinal haemorrhage. severe cardiac arrhythmias
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Avoid in Acute porphyrias p. 1120. coronary artery disease. hypotension
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NICE decisions ▶Cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease (May 2011) NICE TA223 Pentoxifylline is not recommended for the treatment of intermittent claudication in patients with peripheral arterial disease; patients currently receiving this treatment should have the option to continue until they and their clinician consider it appropriate to stop. www.nice.org.uk/guidance/ta223 l LESS SUITABLE FOR PRESCRIBING Less suitable for prescribing.
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→Appendix 1: pentoxifylline
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Agitation. angina pectoris. angioedema. arrhythmias. bronchospasm. cholestasis. constipation. diarrhoea. dizziness. gastrointestinal discomfort. gastrointestinal disorder. haemorrhage. headache. hot flush. hypersalivation. hypotension. leucopenia. meningitis aseptic. nausea. neutropenia. skin reactions. sleep disorder. thrombocytopenia. vomiting
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Manufacturer advises avoid—no information available.
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Present in milk—manufacturer advises use only if potential benefit outweighs risk.
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Manufacturer advises caution in severe impairment. Dose adjustments Manufacturer advises consider dose reduction in severe impairment.
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Dose adjustments Reduce dose by 30–50% if eGFR less than 30 mL/minute/1.73 m2.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral solution Modified-release tablet CAUTIONARY AND ADVISORY LABELS 21, 25 ▶Trental (Sanofi) Pentoxifylline 400 mg Trental 400 modified-release tablets | 90 tablet P £19.39 DT = £19.39 10.1 Vein malformations SCLEROSANTS
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400 mg 2–3 times a day
First-line fragment. Read the complete Indications and Dose section above.
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