Indications And Dose
Monotherapy in Parkinson’s disease where dopamine- receptor agonists other than ergot derivative not appropriate ▶BY MOUTH Nervous system ▶Adult: Initially 50 micrograms once daily for day 1, dose to be taken at bedtime, then 50 micrograms twice daily for days 2–4, then increased in steps of 100–250 micrograms daily, dose to be increased at intervals of 3–4 days, increased to 1.5 mg daily in 3 divided doses at day 28, then increased in steps of up to 250 micrograms every 3–4 days, this increase to be started after day 30; maintenance 2.1–2.5 mg daily; maximum 3 mg per day Adjunctive therapy with co-beneldopa or co-careldopa in Parkinson’s disease where dopamine-receptor agonists other than ergot derivative not appropriate ▶BY MOUTH ▶Adult: Initially 50 micrograms daily for 2 days, then increased in steps of 100–150 micrograms every 3 days, dose to be adjusted over next 12 days following initial dose and usually given in 3 divided doses, then increased in steps of 250 micrograms every 3 days, during pergolide titration, levodopa dose may be reduced cautiously; maximum 3 mg per day
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