Drug reference
Prophylaxis of embolisation in rheumatic heart disease and atrial fibrillation | Prophylaxis after insertion of prosthetic heart valve| Prophylaxis and treatment of venous thrombosis and pulmonary embolism ▶BY MOUTH ▶Adult: Initially 200 mg on day 1, then 100 mg on day 2, then, adjusted according to response; maintenance 50–150 mg daily
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→Appendix 1: phenindione
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Agranulocytosis. albuminuria. eosinophilia . hepatitis. increased leucocytes. kidney injury. leucopenia. lymphadenopathy. pancytopenia. renal tubular necrosis. taste altered
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Avoid. Risk of haemorrhage; increased by vitamin K deficiency.
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Caution in mild to moderate impairment. Avoid in severe impairment.
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 10, 14 ▶Phenindione (Non-proprietary) Phenindione 10 mg Phenindione 10mg tablets | 28 tablet P £600.00 DT = £600.00 Phenindione 25 mg Phenindione 25mg tablets | 28 tablet P £600.00 DT = £600.00 eiiii F 149
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Patient counselling is advised for phenindione tablets (may turn urine pink or orange). Anticoagulant card to be provided.
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Initially 200 mg on day 1, then 100 mg on day 2,
First-line fragment. Read the complete Indications and Dose section above.
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