Drug reference

Phenoxymethylpenicillin

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 600, 601

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Oral infections | Otitis media ▶BY MOUTH ▶Child 1–11 months: 62.5 mg 4 times a day; increased if necessary up to 12.5 mg/kg 4 times a day ▶Child 1–5 years: 125 mg 4 times a day; increased if necessary up to 12.5 mg/kg 4 times a day ▶Child 6–11 years: 250 mg 4 times a day; increased if necessary up to 12.5 mg/kg 4 times a day ▶Child 12–17 years: 500 mg 4 times a day; increased if necessary up to 1 g 4 times a day ▶Adult: 500 mg every 6 hours, increased if necessary up to 1 g every 6 hours Acute sore throat ▶BY MOUTH ▶Child 1–11 months: 62.5 mg 4 times a day, alternatively 125 mg twice daily for 5–10 days ▶Child 1–5 years: 125 mg 4 times a day, alternatively 250 mg twice daily for 5–10 days ▶Child 6–11 years: 250 mg 4 times a day, alternatively 500 mg twice daily for 5–10 days ▶Child 12–17 years: 500 mg 4 times a day, alternatively 1000 mg twice daily for 5–10 days ▶Adult: 500 mg 4 times a day, alternatively 1000 mg twice daily for 5–10 days Prevention of recurrent cellulitis (specialist use only) | Prevention of recurrent erysipelas (specialist use only) ▶BY MOUTH ▶Adult: 250 mg twice daily Prevention of recurrence of rheumatic fever ▶BY MOUTH ▶Child 1 month–5 years: 125 mg twice daily ▶Child 6–17 years: 250 mg twice daily ▶Adult: 250 mg twice daily Prevention of secondary case of invasive group A streptococcal infection ▶BY MOUTH ▶Child 1–11 months: 62.5 mg every 6 hours for 10 days ▶Child 1–5 years: 125 mg every 6 hours for 10 days ▶Child 6–11 years: 250 mg every 6 hours for 10 days ▶Child 12–17 years: 250–500 mg every 6 hours for 10 days ▶Adult: 250–500 mg every 6 hours for 10 days Prevention of pneumococcal infection in asplenia or in patients with sickle-cell disease ▶BY MOUTH ▶Child 1–11 months: 62.5 mg twice daily ▶Child 1–4 years: 125 mg twice daily ▶Child 5–17 years: 250 mg twice daily ▶Adult: 250 mg twice daily Acute sinusitis ▶BY MOUTH ▶Child 1–11 months: 62.5 mg 4 times a day for 5 days ▶Child 1–5 years: 125 mg 4 times a day for 5 days ▶Child 6–11 years: 250 mg 4 times a day for 5 days ▶Child 12–17 years: 500 mg 4 times a day for 5 days ▶Adult: 500 mg 4 times a day for 5 days l UNLICENSED USE g Duration of treatment for acute sinusitis adheres to national guidelines. h See Sinusitis (acute) p. 1268 for further information. g Phenoxymethylpenicillin is used for the prevention of recurrent cellulitis, h but is not licensed for this indication. g Phenoxymethylpenicillin is used for the prevention of recurrent erysipelas, h but is not licensed for this indication. Phenoxymethylpenicillin doses in the BNF may differ from product literature.

PDF pages 600, 601

Prescribing And Dispensing Information

For choice of antibacterial therapy, see Antibacterials, use for prophylaxis p. 529, Ear infections, antibacterial therapy p. 534, Nose infections, antibacterial therapy p. 536, Oral bacterial infections p. 537, Oropharyngeal infections, antibacterial therapy p. 1282, Skin infections, antibacterial therapy p. 540.

PDF page 601

Safety

Interactions

→Appendix 1: penicillins

PDF page 601

Side Effects

Arthralgia. circulatory collapse. coagulation disorder. eosinophilia. faeces soft. fever. increased risk of infection. neurotoxicity. neutropenia. oral disorders. paraesthesia

PDF page 601

Pregnancy

Not known to be harmful.

PDF page 601

Breast Feeding

Trace amounts in milk, but appropriate to use. l EFFECT ON LABORATORY TESTS False-positive urinary glucose (if tested for reducing substances).

PDF page 601

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Oral solution CAUTIONARY AND ADVISORY LABELS 9, 23 ▶Phenoxymethylpenicillin (Non-proprietary) Phenoxymethylpenicillin (as Phenoxymethylpenicillin potassium) 25 mg per 1 ml Phenoxymethylpenicillin 125mg/5ml oral solution | 100 ml P £34.00 DT = £2.53 Phenoxymethylpenicillin 125mg/5ml oral solution sugar-free | 100 ml P £25.00 DT = £7.10 Phenoxymethylpenicillin (as Phenoxymethylpenicillin potassium) 50 mg per 1 ml Phenoxymethylpenicillin 250mg/5ml oral solution | 100 ml P £35.00 DT = £5.81 Phenoxymethylpenicillin 250mg/5ml oral solution sugar-free | 100 ml P £35.00 DT = £7.47 Tablet CAUTIONARY AND ADVISORY LABELS 9, 23 ▶Phenoxymethylpenicillin (Non-proprietary) Phenoxymethylpenicillin (as Phenoxymethylpenicillin potassium) 250 mg Phenoxymethylpenicillin 250mg tablets | 28 tablet P £5.00 DT = £1.14 ANTIBACTERIALS › PENICILLINS, BROAD-SPECTRUM eiiii F 575

PDF page 601

Clinical care

Patient And Carer Advice

Medicines for Children leaflet: Penicillin V for bacterial infections www.medicinesforchildren.org.uk/penicillin-v-bacterial- infections Infection Medicines for Children leaflet: Penicillin V for prevention of pneumococcal infection www.medicinesforchildren.org.uk/ penicillin-v-prevention-pneumococcal-infection l PROFESSION SPECIFIC INFORMATION Dental practitioners’ formulary Phenoxymethylpenicillin Tablets may be prescribed. Phenoxymethylpenicillin Oral Solution may be prescribed.

PDF page 601

Dose text by age group

Child 1–11 months

62.5 mg 4 times a day; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 600

Child 1–5 years

125 mg 4 times a day; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 600

Child 6–11 years

250 mg 4 times a day; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 600

Child 12–17 years

500 mg 4 times a day; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 600

Child 1–11 months

62.5 mg 4 times a day, alternatively

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–5 years

125 mg 4 times a day, alternatively

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 6–11 years

250 mg 4 times a day, alternatively

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 12–17 years

500 mg 4 times a day, alternatively

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1 month–5 years

125 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 6–17 years

250 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–11 months

62.5 mg every 6 hours for 10 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–5 years

125 mg every 6 hours for 10 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 6–11 years

250 mg every 6 hours for 10 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 12–17 years

250–500 mg every 6 hours for 10 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–11 months

62.5 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–4 years

125 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 5–17 years

250 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–11 months

62.5 mg 4 times a day for 5 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–5 years

125 mg 4 times a day for 5 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 6–11 years

250 mg 4 times a day for 5 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 12–17 years

500 mg 4 times a day for 5 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Phenoxymethylpenicillin

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 600, 601

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF pages 600, 601

Prescribing And Dispensing Information

PDF page 601

Safety

Interactions

→Appendix 1: penicillins

PDF page 601

Side Effects

Arthralgia. circulatory collapse. coagulation disorder. eosinophilia. faeces soft. fever. increased risk of infection. neurotoxicity. neutropenia. oral disorders. paraesthesia

PDF page 601

Pregnancy

Not known to be harmful.

PDF page 601

Breast Feeding

Trace amounts in milk, but appropriate to use. l EFFECT ON LABORATORY TESTS False-positive urinary glucose (if tested for reducing substances).

PDF page 601

Dose and formulations

Medicinal Forms

PDF page 601

Clinical care

Patient And Carer Advice

PDF page 601

Dose text by age group

Child 1–11 months

62.5 mg 4 times a day; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 600

Child 1–5 years

125 mg 4 times a day; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 600

Child 6–11 years

250 mg 4 times a day; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 600

Child 12–17 years

500 mg 4 times a day; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 600

Child 1–11 months

62.5 mg 4 times a day, alternatively

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–5 years

125 mg 4 times a day, alternatively

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 6–11 years

250 mg 4 times a day, alternatively

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 12–17 years

500 mg 4 times a day, alternatively

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1 month–5 years

125 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 6–17 years

250 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–11 months

62.5 mg every 6 hours for 10 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–5 years

125 mg every 6 hours for 10 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 6–11 years

250 mg every 6 hours for 10 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 12–17 years

250–500 mg every 6 hours for 10 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–11 months

62.5 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–4 years

125 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 5–17 years

250 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–11 months

62.5 mg 4 times a day for 5 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 1–5 years

125 mg 4 times a day for 5 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 6–11 years

250 mg 4 times a day for 5 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Child 12–17 years

500 mg 4 times a day for 5 days

First-line fragment. Read the complete Indications and Dose section above.

PDF page 601

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.