Drug reference

Piperacillin with tazobactam

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 598

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Hospital-acquired pneumonia | Septicaemia | Complicated infections involving the urinary-tract | Complicated infections involving the skin | Complicated infections involving the soft-tissues | Acute exacerbation of chronic obstructive pulmonary disease | Acute exacerbation of bronchiectasis | Moderate diabetic foot infection | Severe diabetic foot infection | Leg ulcer infection ▶BY INTRAVENOUS INFUSION ▶Adult: 4.5 g every 8 hours; increased if necessary to 4.5 g every 6 hours, increased frequency may be used for severe infections Infections in neutropenic patients ▶BY INTRAVENOUS INFUSION ▶Adult: 4.5 g every 6 hours l UNLICENSED USE g Piperacillin with tazobactam is used for the treatment of acute exacerbation of chronic obstructive pulmonary disease, h but is not licensed for this indication. g Piperacillin with tazobactam is used for the treatment of acute exacerbation of bronchiectasis, h but is not licensed for this indication.

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Cautions

High doses may lead to hypernatraemia (owing to sodium content of preparations)

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Prescribing And Dispensing Information

Dose expressed as a combination of piperacillin and tazobactam (both as sodium salts) in a ratio of 8:1. For choice of antibacterial therapy, see Blood infections, antibacterial therapy p. 532, Diabetic foot infections, antibacterial therapy p. 533, Respiratory system infections, antibacterial therapy p. 538, Skin infections, antibacterial therapy p. 540, Urinary-tract infections p. 622.

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Safety

Interactions

→Appendix 1: penicillins

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Side Effects

▶Common or very common Anaemia. candida infection. constipation. gastrointestinal discomfort. headache. insomnia ▶Uncommon Arthralgia. ﬂushing. hypokalaemia. hypotension. myalgia. thrombophlebitis ▶Rare or very rare Epistaxis. stomatitis ▶Frequency not known Eosinophilia. neutropenia. pancytopenia. pneumonia eosinophilic. renal failure. thrombocytosis

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Pregnancy

Manufacturers advise use only if potential beneﬁt outweighs risk.

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Breast Feeding

Trace amount in milk, but appropriate to use.

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Renal Impairment

Dose adjustments Max. 4.5 g every 8 hours if eGFR 20–40 mL/minute/1.73 m2. Max. 4.5 g every 12 hours if eGFR less than 20 mL/minute/1.73 m2. l EFFECT ON LABORATORY TESTS False-positive urinary glucose (if tested for reducing substances).

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Dose and formulations

Directions For Administration

For intravenous infusion, give intermittently in Glucose 5% or Sodium chloride 0.9%. Reconstitute initially (2.25 g in 10 mL, 4.5 g in 20 mL) with water for injections, or glucose 5% (Tazocin ® brand only), or sodium chloride 0.9%, then dilute to 50–150 mL with infusion ﬂuid; give over 30 minutes.

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Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: infusion, powder for solution for infusion Powder for solution for infusion ELECTROLYTES: May contain Sodium ▶Piperacillin with tazobactam (Non-proprietary) Tazobactam (as Tazobactam sodium) 250 mg, Piperacillin (as Piperacillin sodium) 2 gram Piperacillin 2g / Tazobactam 250mg powder for solution for infusion vials | 1 vial P £9.55 DT = £7.65 (Hospital only) | 10 vial P £86.40 (Hospital only) Tazobactam (as Tazobactam sodium) 500 mg, Piperacillin (as Piperacillin sodium) 4 gram Piperacillin 4g / Tazobactam 500mg powder for solution for infusion vials | 1 vial P £15.75–£19.97 (Hospital only) | 1 vial P £12.90 | 10 vial P £48.00–£76.50 | 10 vial P £99.00 (Hospital only) ▶Tazocin (Pfizer Ltd) Tazobactam (as Tazobactam sodium) 250 mg, Piperacillin (as Piperacillin sodium) 2 gram Tazocin 2g/0.25g powder for solution for infusion vials | 1 vial P £7.65 DT = £7.65 Tazobactam (as Tazobactam sodium) 500 mg, Piperacillin (as Piperacillin sodium) 4 gram Tazocin 4g/0.5g powder for solution for infusion vials | 1 vial P £15.17 eiiii F 575

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Dose text by age group

Adult

4.5 g every 8 hours; increased if necessary to

First-line fragment. Read the complete Indications and Dose section above.

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Adult

4.5 g every 6 hours

First-line fragment. Read the complete Indications and Dose section above.

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Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Piperacillin with tazobactam

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 598

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 598

Cautions

High doses may lead to hypernatraemia (owing to sodium content of preparations)

PDF page 598

Prescribing And Dispensing Information

PDF page 598

Safety

Interactions

→Appendix 1: penicillins

PDF page 598

Side Effects

PDF page 598

Pregnancy

Manufacturers advise use only if potential beneﬁt outweighs risk.

PDF page 598

Breast Feeding

Trace amount in milk, but appropriate to use.

PDF page 598

Renal Impairment

PDF page 598

Dose and formulations

Directions For Administration

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Medicinal Forms

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Dose text by age group

Adult

4.5 g every 8 hours; increased if necessary to

First-line fragment. Read the complete Indications and Dose section above.

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Adult

4.5 g every 6 hours

First-line fragment. Read the complete Indications and Dose section above.

PDF page 598

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.