Drug reference
Adjunctive treatment of cortical myoclonus ▶BY MOUTH ▶Adult: Initially 7.2 g daily in 2–3 divided doses, then increased in steps of 4.8 g every 3–4 days, adjusted according to response, subsequently, attempts should be made to reduce dose of concurrent therapy; maximum 24 g per day
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Cerebral haemorrhage. Huntington’s chorea
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Gastric ulcer. history of haemorrhagic stroke. increased risk of bleeding. major surgery. underlying disorders of haemostasis
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Piracetam has been used in children 16 years and over as adjunctive treatment for cortical myoclonus.
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▶Common or very common Anxiety. movement disorders. weight increased ▶Uncommon Asthenia. depression. drowsiness ▶Frequency not known Angioedema. confusion. diarrhoea. epilepsy exacerbated. gastrointestinal discomfort. haemorrhagic disorder. hallucination. headache. insomnia. nausea. skin reactions. vertigo. vomiting
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Avoid.
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Avoid.
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Manufacturer advises caution in combined hepatic and renal impairment. Dose adjustments Manufacturer advises dose reduction in combined hepatic and renal impairment.
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Avoid if eGFR less than 20 mL/minute/1.73 m2. Dose adjustments Use two-thirds of normal dose if eGFR 50–80 mL/minute/1.73 m2; use one-third of normal dose in 2 divided doses if eGFR 30–50 mL/minute/1.73 m2; use one-sixth of normal dose as a single dose if eGFR 20–30 mL/minute/1.73 m2.
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Follow the oral solution with a glass of water (or soft drink) to reduce bitter taste.
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There can be variation in the licensing of different medicines containing the same drug. Oral solution CAUTIONARY AND ADVISORY LABELS 3 ▶Nootropil (UCB Pharma Ltd) Piracetam 333.3 mg per 1 ml Nootropil 33% oral solution sugar-free | 300 ml P £16.31 DT = £16.31 Tablet CAUTIONARY AND ADVISORY LABELS 3 ▶Nootropil (UCB Pharma Ltd) Piracetam 800 mg Nootropil 800mg tablets | 90 tablet P £11.75 DT = £11.75 Piracetam 1.2 gram Nootropil 1200mg tablets | 60 tablet P £10.97 DT = £10.97 MONOAMINE DEPLETING DRUGS
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Avoid abrupt withdrawal.
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Initially 7.2 g daily in 2–3 divided doses, then
First-line fragment. Read the complete Indications and Dose section above.
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