Drug reference

Pivmecillinam hydrochloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 607, 608

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Acute uncomplicated cystitis ▶BY MOUTH ▶Child (body-weight 40 kg and above): Initially 400 mg for 1 dose, then 200 mg every 8 hours to a total of continued → 10 tablets ▶Adult (body-weight 40 kg and above): Initially 400 mg for 1 dose, then 200 mg every 8 hours to a total of 10 tablets Chronic or recurrent bacteriuria ▶BY MOUTH ▶Child (body-weight 40 kg and above): 400 mg every 6–8 hours ▶Adult (body-weight 40 kg and above): 400 mg every Infection 6–8 hours Urinary-tract infections ▶BY MOUTH ▶Child (body-weight up to 40 kg): 5–10 mg/kg every 6 hours, alternatively 20–40 mg/kg daily in 3 divided doses l UNLICENSED USE ▶In children Not licensed for use in children under 3 months.

PDF pages 607, 608

Contra Indications

Carnitine deﬁciency. gastro- intestinal obstruction. oesophageal strictures

PDF page 608

Cautions

Avoid in Acute porphyrias p. 1120

PDF page 608

Safety

Interactions

→Appendix 1: penicillins

PDF page 608

Side Effects

▶Common or very common Vulvovaginal fungal infection ▶Uncommon Dizziness. fatigue. gastrointestinal discomfort . gastrointestinal disorders. headache. oral ulceration. vertigo

PDF page 608

Pregnancy

Not known to be harmful, but manufacturer advises avoid.

PDF page 608

Breast Feeding

Trace amount in milk, but appropriate to use.

PDF page 608

Monitoring Requirements

Liver and renal function tests required in long-term use. l EFFECT ON LABORATORY TESTS False positive urinary glucose (if tested for reducing substances). False positive newborn screening results for isovaleric acidaemia may occur in neonates born to mothers receiving pivmecillinam during late pregnancy.

PDF page 608

Dose and formulations

Directions For Administration

Tablets should be swallowed whole with plenty of ﬂuid during meals while sitting or standing.

PDF page 608

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 9, 21, 27 ▶Pivmecillinam hydrochloride (Non-proprietary) Pivmecillinam hydrochloride 200 mg Pivmecillinam 200mg tablets | 10 tablet P £5.40 DT = £5.40 ▶Selexid (Karo Pharma) Pivmecillinam hydrochloride 200 mg Selexid 200mg tablets | 10 tablet P £5.40 DT = £5.40 | 18 tablet P £9.72 ANTIBACTERIALS › PENICILLINS, PENICILLINASE-RESISTANT eiiii F 575

PDF page 608

Clinical care

Patient And Carer Advice

Patient counselling is advised on administration of pivmecillinam hydrochloride tablets (posture).

PDF page 608

Dose text by age group

Child (body-weight 40 kg and above)

Initially 400 mg for

First-line fragment. Read the complete Indications and Dose section above.

PDF page 607

Adult (body-weight 40 kg and above)

Initially 400 mg for

First-line fragment. Read the complete Indications and Dose section above.

PDF page 608

Child (body-weight 40 kg and above)

400 mg every

First-line fragment. Read the complete Indications and Dose section above.

PDF page 608

Adult (body-weight 40 kg and above)

400 mg every

First-line fragment. Read the complete Indications and Dose section above.

PDF page 608

Child (body-weight up to 40 kg)

5–10 mg/kg every

First-line fragment. Read the complete Indications and Dose section above.

PDF page 608

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Pivmecillinam hydrochloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 607, 608

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF pages 607, 608

Contra Indications

Carnitine deﬁciency. gastro- intestinal obstruction. oesophageal strictures

PDF page 608

Cautions

Avoid in Acute porphyrias p. 1120

PDF page 608

Safety

Interactions

→Appendix 1: penicillins

PDF page 608

Side Effects

▶Common or very common Vulvovaginal fungal infection ▶Uncommon Dizziness. fatigue. gastrointestinal discomfort . gastrointestinal disorders. headache. oral ulceration. vertigo

PDF page 608

Pregnancy

Not known to be harmful, but manufacturer advises avoid.

PDF page 608

Breast Feeding

Trace amount in milk, but appropriate to use.

PDF page 608

Monitoring Requirements

PDF page 608

Dose and formulations

Directions For Administration

Tablets should be swallowed whole with plenty of ﬂuid during meals while sitting or standing.

PDF page 608

Medicinal Forms

PDF page 608

Clinical care

Patient And Carer Advice

Patient counselling is advised on administration of pivmecillinam hydrochloride tablets (posture).

PDF page 608

Dose text by age group

Child (body-weight 40 kg and above)

Initially 400 mg for

First-line fragment. Read the complete Indications and Dose section above.

PDF page 607

Adult (body-weight 40 kg and above)

Initially 400 mg for

First-line fragment. Read the complete Indications and Dose section above.

PDF page 608

Child (body-weight 40 kg and above)

400 mg every

First-line fragment. Read the complete Indications and Dose section above.

PDF page 608

Adult (body-weight 40 kg and above)

400 mg every

First-line fragment. Read the complete Indications and Dose section above.

PDF page 608

Child (body-weight up to 40 kg)

5–10 mg/kg every

First-line fragment. Read the complete Indications and Dose section above.

PDF page 608

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.