Names and pronunciation
(ple-kan′-a-tide) Trulance
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Drug reference
(ple-kan′-a-tide) Trulance
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Func. class.: Laxative
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Chem. class.: Guanylate cyclase-C agonist
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ACTION: Binds to GC-C and acts locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extra cellular concentrations of cyclic guanosine monophosphate (cGMP); this action results in increased intestinal fluid and accelerated gastrointestinal (GI) transit
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USES: Chronic idiopathic constipation, IBS-C
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CONTRAINDICATIONS: Hyper sensitivity, GI obstruction
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Black Box Warning: Child <6 yr Precautions: Pregnancy, breastfeeding
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SIDE EFFECTS CNS: Dizziness GI: Diarrhea, flatulence, abdominal dis- tention, abdominal tenderness, nausea GU: UTI RESP: Sinusitis, upper respiratory tract infection
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INTERACTIONS Drug/Lab Test Increase: AST/ALT
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DOSAGE AND ROUTES • Adult: PO 3 mg daily
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Available forms: Tabs 3 mg
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Administer: • Give without regard to food • Swallow whole; tablets may be crushed and given with applesauce or in water, may be given orally or via NG tube
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Assess: Bowel pattern: frequency, consistency, baseline and periodically; provide ade- quate hydration if diarrhea occurs
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Evaluate: • Therapeutic response: complete bowel movements
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: • Pregnancy/breastfeeding: to notify health care professional if pregnancy is planned or suspected or if breastfeeding • To notify all health care professionals of all OTC, Rx, herbals or supplements taken • To take as directed, not to double or skip doses; that if dose is missed, to take next regularly scheduled dose when due
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PHARMACOKINETICS Unknown
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• Adult: PO 3 mg daily
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