Indications And Dose
PREVENAR 13 ® Primary immunisation against pneumococcal infection— first dose [infants born on or after 1 January 2020] ▶BY INTRAMUSCULAR INJECTION ▶Child 12 weeks: 0.5 mL for 1 dose, anterolateral thigh is preferred site of injection in infants under 1 year Primary immunisation against pneumococcal infection— booster dose [infants born on or after 1 January 2020] ▶BY INTRAMUSCULAR INJECTION ▶Child 1 year: 0.5 mL for 1 dose, anterolateral thigh is preferred site of injection in infants under 1 year; deltoid muscle is preferred in older children Primary immunisation against pneumococcal infection—in those with asplenia, splenic dysfunction, complement disorder or severe immunocompromise [infants born on or after 1 January 2020] ▶BY INTRAMUSCULAR INJECTION ▶Child 6 weeks–11 months: 0.5 mL for 4 doses, the first two doses to be given at least 8 weeks apart, the third dose to be given on or after their first birthday, and the fourth dose to be given at least 8 weeks later. Anterolateral thigh is preferred site of injection in infants under 1 year; deltoid muscle is preferred in children Immunisation against pneumococcal infection— unimmunised or partially immunised patients [infants born on or after 1 January 2020] ▶BY INTRAMUSCULAR INJECTION ▶Child 3–11 months: 0.5 mL for 1 dose, followed by 0.5 mL for 1 dose on or after their first birthday, given at least 4 weeks after the first dose. Anterolateral thigh is preferred site of injection in infants under 1 year ▶Child 12–23 months: 0.5 mL for 1 dose, deltoid muscle is continued → preferred site of injection in children Immunisation against pneumococcal infection— unimmunised or partially immunised patients at increased risk [born on or after 1 January 2020] ▶BY INTRAMUSCULAR INJECTION ▶Child 2–9 years: 0.5 mL for 1 dose, deltoid muscle is preferred site of injection in children Immunisation against pneumococcal infection— immunised patients with severe immunocompromise [born on or after 1 January 2020] ▶BY INTRAMUSCULAR INJECTION ▶Child 2–17 years: 0.5 mL for 1 dose, deltoid muscle is preferred site of injection in children ▶Adult: 0.5 mL for 1 dose, deltoid muscle is preferred site of injection in adults Primary immunisation against pneumococcal infection— first dose [infants born on or before 31 December 2019] ▶BY INTRAMUSCULAR INJECTION ▶Child 8 weeks: 0.5 mL for 1 dose, anterolateral thigh is preferred site of injection in infants under 1 year Primary immunisation against pneumococcal infection— Vaccines second dose [infants born on or before 31 December 2019] ▶BY INTRAMUSCULAR INJECTION ▶Child 16 weeks: 0.5 mL for 1 dose, anterolateral thigh is preferred site of injection in infants under 1 year Primary immunisation against pneumococcal infection— booster dose [infants born on or before 31 December 2019] ▶BY INTRAMUSCULAR INJECTION ▶Child 1 year: 0.5 mL for 1 dose, anterolateral thigh is preferred site of injection in infants under 1 year; deltoid muscle is preferred in older children Immunisation against pneumococcal infection— unimmunised or partially immunised patients [infants born on or before 31 December 2019] ▶BY INTRAMUSCULAR INJECTION ▶Child 3–11 months: 0.5 mL for 2 doses, given 2 months apart (interval may be reduced to 1 month to ensure immunisation schedule is completed), followed by 0.5 mL for 1 dose on their first birthday, given at least 2 months after the last dose. Anterolateral thigh is preferred site of injection in infants under 1 year ▶Child 12–23 months: 0.5 mL for 1 dose, deltoid muscle is preferred site of injection in children Immunisation against pneumococcal infection— immunised patients at increased risk [born on or before 31 December 2019] ▶BY INTRAMUSCULAR INJECTION ▶Child 14 months–17 years: 0.5 mL for 1 dose, given at least 2 months after primary immunisation booster dose, deltoid muscle is preferred site of injection in children ▶Adult: 0.5 mL for 1 dose, deltoid muscle is preferred site of injection in adults Immunisation against pneumococcal infection— unimmunised or partially immunised patients at increased risk [born on or before 31 December 2019] ▶BY INTRAMUSCULAR INJECTION ▶Child 3–11 months: 0.5 mL for 2 doses, given 2 months apart (interval may be reduced to 1 month to ensure immunisation schedule is completed), followed by 0.5 mL for 1 dose on their first birthday, given at least 2 months after the last dose, followed by 0.5 mL for 1 dose, given at least 2 months after the last dose. Anterolateral thigh is preferred site of injection in infants under 1 year ▶Adult: 0.5 mL for 1 dose, deltoid muscle is preferred site of injection in adults SYNFLORIX ® Immunisation against pneumococcal infection ▶BY INTRAMUSCULAR INJECTION ▶Child 6 weeks–4 years: Deltoid muscle is preferred site of injection in young children; anterolateral thigh is preferred site in infants (consult product literature) l UNLICENSED USE PREVENAR 13 ® The dose in BNF publications may differ from that in product literature.
PDF pages 1407, 1408