Indications And Dose
Invasive aspergillosis either refractory to, or in patients intolerant of, itraconazole or amphotericin | Fusariosis either refractory to, or in patients intolerant of, amphotericin | Chromoblastomycosis and mycetoma either refractory to, or in patients intolerant of, Infection itraconazole | Coccidioidomycosis either refractory to, or in patients intolerant of, amphotericin, itraconazole, or fluconazole ▶BY MOUTH USING ORAL SUSPENSION ▶Adult: 400 mg twice daily, to be taken with food, alternatively 200 mg 4 times a day, if unable to tolerate food ▶BY MOUTH USING TABLETS, OR BY INTRAVENOUS INFUSION ▶Adult: Loading dose 300 mg twice daily on first day, then 300 mg once daily, switch from intravenous to oral route when appropriate Oropharyngeal candidiasis (severe infection or in immunocompromised patients only) ▶BY MOUTH USING ORAL SUSPENSION ▶Adult: Loading dose 200 mg on first day, then 100 mg once daily for 13 days, dose to be taken with food Prophylaxis of invasive fungal infections in patients at high risk and undergoing high-dose immunosuppressive therapy for haematopoietic stem cell transplantation or receiving chemotherapy for acute myeloid leukaemia or myelodysplastic syndrome and expected to develop prolonged neutropenia ▶BY MOUTH USING ORAL SUSPENSION ▶Adult: 200 mg 3 times a day, dose to be taken with food, for chemotherapy patients, start several days before the expected onset of neutropenia and continue for 7 days after neutrophil count rises above 500 cells/mm3 ▶BY MOUTH USING TABLETS, OR BY INTRAVENOUS INFUSION ▶Adult: Loading dose 300 mg twice daily on first day, then 300 mg once daily, for chemotherapy patients, start several days before the expected onset of neutropenia and continue for 7 days after neutrophil count rises above 500 cells/mm3, switch from intravenous to oral route when appropriate DOSE EQUIVALENCE AND CONVERSION ▶Posaconazole oral suspension is not interchangeable with tablets on a milligram-for-milligram basis.
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