Drug reference

Pralidoxime chloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1461

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Adjunct to atropine in the treatment of poisoning by organophosphorus insecticide or nerve agent ▶BY INTRAVENOUS INFUSION ▶Child: Initially 30 mg/kg, to be given over 20 minutes, followed by 8 mg/kg/hour; maximum 12 g per day ▶Adult: Initially 30 mg/kg, to be given over 20 minutes, followed by 8 mg/kg/hour; maximum 12 g per day l UNLICENSED USE Pralidoxime chloride doses may differ from those in product literature. ▶In children Licensed for use in children (age range not speciﬁed by manufacturer).

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Contra Indications

Poisoning with carbamates. poisoning with organophosphorus compounds without anticholinesterase activity

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Cautions

Myasthenia gravis

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Prescribing And Dispensing Information

Available from designated centres for organophosphorus insecticide poisoning or from the National Blood Service (or Welsh Ambulance Services for Mid West and South East Wales)— see TOXBASE for list of designated centres).

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Exceptions To Legal Category

Prescription only medicine restriction does not apply where administration is for saving life in emergency.

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Safety

Side Effects

Dizziness. drowsiness. headache. hyperventilation. muscle weakness. nausea. tachycardia. vision disorders

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Renal Impairment

Use with caution.

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Dose and formulations

Directions For Administration

The loading dose may be administered by intravenous injection (diluted to a concentration of 50 mg/mL with water for injections) over at least 5 minutes if pulmonary oedema is present or if it is not practical to administer an intravenous infusion. ▶In children For intravenous infusion, reconstitute each vial with 20 mL Water for Injections, then dilute to a concentration of 10–20 mg/mL with Sodium Chloride 0.9%.

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Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Powder for solution for injection ▶Protopam (Imported (United States)) Pralidoxime chloride 1 gram Protopam Chloride 1g powder for solution for injection vials | 6 vial P s Drug toxicity 3.1 Benzodiazepine toxicity ANTIDOTES AND CHELATORS › BENZODIAZEPINE ANTAGONISTS

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Dose text by age group

Adult

Initially 30 mg/kg, to be given over 20 minutes,

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1461

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Pralidoxime chloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1461

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 1461

Contra Indications

Poisoning with carbamates. poisoning with organophosphorus compounds without anticholinesterase activity

PDF page 1461

Cautions

Myasthenia gravis

PDF page 1461

Prescribing And Dispensing Information

PDF page 1461

Exceptions To Legal Category

Prescription only medicine restriction does not apply where administration is for saving life in emergency.

PDF page 1461

Safety

Side Effects

Dizziness. drowsiness. headache. hyperventilation. muscle weakness. nausea. tachycardia. vision disorders

PDF page 1461

Renal Impairment

Use with caution.

PDF page 1461

Dose and formulations

Directions For Administration

PDF page 1461

Medicinal Forms

PDF page 1461

Dose text by age group

Adult

Initially 30 mg/kg, to be given over 20 minutes,

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1461

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.