Names and pronunciation
(pra-li-doks′eem) Protopam Chloride
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Drug reference
(pra-li-doks′eem) Protopam Chloride
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Func. class.: Antidote
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USES: Treatment of muscle weak- ness and/or respiratory depression secondary to poisoning due to organo- phosphate anticholinesterase pesti- cides and terrorism nerve agents; control of overdose of anticholinester- ase medications used to treat myasthe- nia gravis (ambenonium, neostigmine, pyridostigmine)
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CONTRAINDICATIONS Hypersensitivity
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DOSAGE AND ROUTES Organophosphate poisoning (pesti- cides and nerve agents) • Adult/adolescents ≥17 yr: IV 1-2 g as a 15- to 30-min infusion in 100 mL NS after reconstitution with 1000 mg/20 mL ster- ile water Loading dose Neonate/infant/child ≤16 yr: IV loading dose 20-50 mg/kg (max 2 g) infused over 15-30 min, then 10-20 mg/kg/hr continuous IV infusion Anticholinesterase overdose (neo- stigmine, pyridostigmine) • Adult: IV 1-2 g mg; then increments of 250 mg q5min as needed
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Available forms: Powder for solution for injection 1 g
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• Adult/adolescents ≥17 yr: IV 1-2 g as a 15- to 30-min infusion in 100 mL NS after reconstitution with 1000 mg/20 mL ster- ile water Loading dose Neonate/infant/child ≤16 yr: IV loading dose 20-50 mg/kg (max 2 g) infused over 15-30 min, then 10-20 mg/kg/hr continuous IV infusion Anticholinesterase overdose (neo- stigmine, pyridostigmine)
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