Indications And Dose
Parkinson’s disease, used alone or as an adjunct to co- beneldopa or co-careldopa ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 88 micrograms 3 times a day, if tolerated dose to be increased by doubling dose every 5–7 days, increased to 350 micrograms 3 times a day, then increased in steps of 180 micrograms 3 times a day if required, dose to be increased at weekly intervals, during dose titration and maintenance, levodopa dose may be reduced, maximum daily dose to be given in 3 divided doses; maximum 3.3 mg per day ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: Initially 260 micrograms once daily, dose to be increased by doubling dose every 5–7 days, increased to 1.05 mg once daily, then increased in steps of 520 micrograms every week if required, during dose titration and maintenance, levodopa dose may be reduced according to response; maximum 3.15 mg per day Moderate to severe restless legs syndrome ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 88 micrograms once daily, dose to be taken 2–3 hours before bedtime, dose to be increased by doubling dose every 4–7 days if necessary, repeat dose titration if restarting treatment after an interval of more than a few days; maximum 540 micrograms per day DOSE EQUIVALENCE AND CONVERSION ▶Doses and strengths are stated in terms of pramipexole (base). ▶Equivalent strengths of pramipexole (base) in terms of pramipexole dihydrochloride monohydrate (salt) for immediate-release preparations are as follows: ▶88 micrograms base : 125 micrograms salt; ▶180 micrograms base : 250 micrograms salt; ▶350 micrograms base : 500 micrograms salt; ▶700 micrograms base : 1 mg salt. ▶Equivalent strengths of pramipexole (base) in terms of pramipexole dihydrochloride monohydrate (salt) for modified-release preparations are as follows: ▶260 micrograms base : 375 micrograms salt; ▶520 micrograms base : 750 micrograms salt; ▶1.05 mg base : 1.5 mg salt; ▶1.57 mg base : 2.25 mg salt; ▶2.1 mg base : 3 mg salt; ▶2.62 mg base : 3.75 mg salt; ▶3.15 mg base : 4.5 mg salt.
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