Drug reference

Pravastatin sodium

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 238

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Adjunct to diet for primary hypercholesterolaemia or combined (mixed) hyperlipidaemias in patients who have not responded adequately to dietary control ▶BY MOUTH ▶Adult: 10–40 mg daily, dose to be taken at night, dose to be adjusted at intervals of at least 4 weeks Prevention of cardiovascular events in patients with previous myocardial infarction or unstable angina | Adjunct to diet to prevent cardiovascular events in patients with hypercholesterolaemia ▶BY MOUTH ▶Adult: 40 mg daily, dose to be taken at night Reduction of hyperlipidaemia in patients receiving immunosuppressive therapy following solid-organ transplantation ▶BY MOUTH ▶Adult: Initially 20 mg daily, then increased if necessary up to 40 mg daily, dose to be taken at night, close medical supervision is required if dose is increased to maximum dose

PDF page 238

Dose Adjustments

DUE TO INTERACTIONS ▶Manufacturer advises reduce dose by half with concurrent use of ombitasvir with paritaprevir and ritonavir. ▶Manufacturer advises max. 20 mg daily with concurrent use of glecaprevir with pibrentasvir. ▶Manufacturer advises max. 40 mg daily with concurrent use of sofosbuvir with velpatasvir and voxilaprevir.

PDF page 238

Safety

Interactions

→Appendix 1: statins

PDF page 238

Side Effects

▶Uncommon Hair abnormal. scalp abnormal. urinary disorders. vision disorders

PDF page 238

Breast Feeding

Manufacturer advises avoid—small amount of drug present in breast milk.

PDF page 238

Hepatic Impairment

Dose adjustments Manufacturer advises initial dose reduction to 10 mg daily; adjust according to response.

PDF page 238

Renal Impairment

Dose adjustments Manufacturer advises initial dose of 10 mg once daily in moderate to severe impairment.

PDF page 238

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet ▶Pravastatin sodium (Non-proprietary) Pravastatin sodium 10 mg Pravastatin 10mg tablets | 28 tablet P £2.68 DT = £0.95 Pravastatin sodium 20 mg Pravastatin 20mg tablets | 28 tablet P £3.05 DT = £1.17 Pravastatin sodium 40 mg Pravastatin 40mg tablets | 28 tablet P £3.82 DT = £1.43 eiiii F 214

PDF page 238

Clinical care

Patient And Carer Advice

Patient counselling is advised for pravastatin tablets (muscle effects).

PDF page 238

Dose text by age group

Adult

10–40 mg daily, dose to be taken at night, dose

First-line fragment. Read the complete Indications and Dose section above.

PDF page 238

Adult

40 mg daily, dose to be taken at night

First-line fragment. Read the complete Indications and Dose section above.

PDF page 238

Adult

Initially 20 mg daily, then increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 238

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Pravastatin sodium

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 238

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 238

Dose Adjustments

PDF page 238

Safety

Interactions

→Appendix 1: statins

PDF page 238

Side Effects

▶Uncommon Hair abnormal. scalp abnormal. urinary disorders. vision disorders

PDF page 238

Breast Feeding

Manufacturer advises avoid—small amount of drug present in breast milk.

PDF page 238

Hepatic Impairment

Dose adjustments Manufacturer advises initial dose reduction to 10 mg daily; adjust according to response.

PDF page 238

Renal Impairment

Dose adjustments Manufacturer advises initial dose of 10 mg once daily in moderate to severe impairment.

PDF page 238

Dose and formulations

Medicinal Forms

PDF page 238

Clinical care

Patient And Carer Advice

Patient counselling is advised for pravastatin tablets (muscle effects).

PDF page 238

Dose text by age group

Adult

10–40 mg daily, dose to be taken at night, dose

First-line fragment. Read the complete Indications and Dose section above.

PDF page 238

Adult

40 mg daily, dose to be taken at night

First-line fragment. Read the complete Indications and Dose section above.

PDF page 238

Adult

Initially 20 mg daily, then increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 238

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.