Drug Action
Procarbazine is a mild monoamine-oxidase inhibitor.
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Drug reference
Procarbazine is a mild monoamine-oxidase inhibitor.
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Hodgkin’s lymphoma ▶BY MOUTH ▶Adult: (consult local protocol)
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Pre-existing severe leucopenia. pre-existing severe thrombocytopenia
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Cardiovascular disease. cerebrovascular disease . epilepsy. phaeochromocytoma. procarbazine is a mild monoamineoxidase inhibitor (dietary restriction is rarely considered necessary)
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RISKS OF INCORRECT DOSING OF ORAL ANTI-CANCER MEDICINES See Cytotoxic drugs p. 938.
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→Appendix 1: procarbazine
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▶Common or very common Appetite decreased ▶Frequency not known Azoospermia. hepatic disorders. infection. lethargy. leucopenia. nausea. neutropenia. ovarian failure. pneumonitis. skin reactions. thrombocytopenia. vomiting
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Contraceptive advice required, see Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Avoid (teratogenic in animal studies and isolated reports in humans). See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Discontinue breast-feeding.
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Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment.
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Caution in mild to moderate Immune system and malignant disease impairment. Avoid in severe impairment.
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There can be variation in the licensing of different medicines containing the same drug. Capsule CAUTIONARY AND ADVISORY LABELS 4 ▶Procarbazine (Non-proprietary) Procarbazine (as Procarbazine hydrochloride) 50 mg Procarbazine 50mg capsules | 50 capsule P £411.35– £479.63 DT = £445.49
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(consult local protocol)
First-line fragment. Read the complete Indications and Dose section above.
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