Drug Action
Procyclidine exerts its antiparkinsonian action by reducing the effects of the relative central cholinergic excess that occurs as a result of dopamine deficiency.
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Drug reference
Procyclidine exerts its antiparkinsonian action by reducing the effects of the relative central cholinergic excess that occurs as a result of dopamine deficiency.
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Parkinsonism | Extrapyramidal symptoms (but not tardive dyskinesia) ▶BY MOUTH ▶Adult: 2.5 mg 3 times a day, then increased in steps of 2.5–5 mg daily if required; increased if necessary up to 30 mg daily in 2–4 divided doses, to be increased at 2–3 day intervals. Maximum daily dose only to be used in exceptional circumstances; maximum 60 mg per day ▶Elderly: Lower end of range preferable Acute dystonia ▶BY INTRAMUSCULAR INJECTION, OR BY INTRAVENOUS INJECTION ▶Adult: 5–10 mg, occasionally, more than 10 mg, dose usually effective in 5–10 minutes but may need 30 minutes for relief ▶Elderly: Lower end of range preferable
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Gastro-intestinal obstruction
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Cardiovascular disease. elderly. hypertension. liable to abuse. prostatic hypertrophy. psychotic disorders . pyrexia. those susceptible to angle-closure glaucoma
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→Appendix 1: procyclidine
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▶Common or very common Constipation. dry mouth. urinary retention. vision blurred ▶Uncommon Anxiety. cognitive impairment. confusion. dizziness. gingivitis. hallucination. memory loss. nausea. rash. vomiting ▶Rare or very rare Psychotic disorder
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Use only if potential benefit outweighs risk.
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No information available.
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Manufacturer advises caution.
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Use with caution.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Solution for injection ▶Procyclidine hydrochloride (Non-proprietary) Procyclidine hydrochloride 5 mg per 1 ml Procyclidine 10mg/2ml solution for injection ampoules | 5 ampoule P £72.50–£73.16 DT = £73.16 Oral solution ▶Procyclidine hydrochloride (Non-proprietary) Procyclidine hydrochloride 500 microgram per 1 ml Procyclidine 2.5mg/5ml oral solution sugar-free | 150 ml P £17.10 DT = £14.02 Procyclidine hydrochloride 1 mg per 1 ml Procyclidine 5mg/5ml oral solution sugar-free | 150 ml P £24.63 DT = £21.67 Tablet ▶Procyclidine hydrochloride (Non-proprietary) Procyclidine hydrochloride 5 mg Procyclidine 5mg tablets | 28 tablet P £12.65 DT = £1.62 | 100 tablet P £5.79–£8.94 | 500 tablet P £28.93–£44.63 ▶Kemadrin (Aspen Pharma Trading Ltd) Procyclidine hydrochloride 5 mg Kemadrin 5mg tablets | 100 tablet P £4.72 | 500 tablet P £23.62 Nervous system
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Avoid abrupt withdrawal in patients taking long-term treatment.
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Driving and skilled tasks May affect performance of skilled tasks (e.g. driving).
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2.5 mg 3 times a day, then increased in steps of
First-line fragment. Read the complete Indications and Dose section above.
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Lower end of range preferable
First-line fragment. Read the complete Indications and Dose section above.
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5–10 mg, occasionally, more than 10 mg, dose
First-line fragment. Read the complete Indications and Dose section above.
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Lower end of range preferable
First-line fragment. Read the complete Indications and Dose section above.
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