Therapeutic Action
Sedating H1 antihistamine
PDF page 265
Loading InternPractice…
Drug reference
Sedating H1 antihistamine
PDF page 265
Insomnia Agitation or aggressive behaviour in patients with acute or chronic psychosis, in combination with haloperidol
PDF page 265
Administer with caution and monitor use: in older patients; in patients with prostate disorders, closed-angle glaucoma, epilepsy, orthostatic hypotension, severe renal or hepatic impairment; in patients taking central nervous system depressants (opioid analgesics, antipsychotics, sedatives, antidepressants, etc.) or drugs known to have an anticholinergic effect (atropine, amitriptyline, chlorpromazine, etc.). May cause: drowsiness (caution when driving/operating machinery), dizziness, headache, confusional state, hypotension, photosensitivity (protect skin from sun exposure); anticholinergic effects (dry mouth, constipation, blurred vision, tachycardia, disorders of micturition); rarely: seizures, extrapyramidal symptoms, neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), allergic reactions. Avoid alcohol during treatment (increased risk of adverse effects). Pregnancy and breast-feeding: avoid
PDF pages 265, 266
25 mg tablet
PDF page 265
Insomnia Adult: 25 mg once daily at bedtime for 7 to 10 days max. Agitation or aggressive behaviour in patients with acute or chronic psychosis, with haloperidol Adult: 25 mg, to be repeated after 60 minutes if necessary
PDF page 265
Promethazine is not included in the WHO list of essential medicines.
PDF page 266
– – Below 25 °C
PDF page 266
25 mg once daily at bedtime for 7 to 10 days max.
PDF page 265
25 mg, to be repeated after 60 minutes if necessary
PDF page 265