Drug reference

Promethazine teoclate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 480

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Nausea | Vomiting | Labyrinthine disorders ▶BY MOUTH ▶Child 5–9 years: 12.5–37.5 mg daily ▶Child 10–17 years: 25–75 mg daily; maximum 100 mg per day ▶Adult: 25–75 mg daily; maximum 100 mg per day Motion sickness prevention (acts longer than promethazine hydrochloride) ▶BY MOUTH ▶Child 5–9 years: 12.5 mg once daily, dose to be taken at bedtime on night before travel or 1–2 hours before travel ▶Child 10–17 years: 25 mg once daily, dose to be taken at bedtime on night before travel or 1–2 hours before travel ▶Adult: 25 mg once daily, dose to be taken at bedtime on night before travel or 1–2 hours before travel Motion sickness treatment (acts longer than promethazine hydrochloride) ▶BY MOUTH ▶Child 5–9 years: 12.5 mg, dose to be taken at onset of motion sickness, then 12.5 mg daily for 2 days, dose to be taken at bedtime ▶Child 10–17 years: 25 mg, dose to be taken at onset of motion sickness, then 25 mg once daily for 2 days, dose to be taken at bedtime ▶Adult: 25 mg, dose to be taken at onset of motion sickness, then 25 mg once daily for 2 days, dose to be taken at bedtime

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Cautions

Asthma. bronchiectasis. bronchitis. epilepsy. prostatic hypertrophy (in adults). pyloroduodenal obstruction. Reye’s syndrome. severe coronary artery disease. susceptibility to angle-closure glaucoma. urinary retention

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Safety

Important Safety Information

MHRA/CHM ADVICE: OVER-THE-COUNTER COUGH AND COLD MEDICINES FOR CHILDREN (APRIL 2009) Children under 6 years should not be given over-the- counter cough and cold medicines containing promethazine.

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Interactions

→Appendix 1: antihistamines, sedating

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Side Effects

Anticholinergic syndrome. anxiety. appetite decreased. arrhythmia. blood disorder. bronchial secretion viscosity increased. confusion. dizziness. drowsiness. dry mouth. epigastric discomfort. fatigue. haemolytic anaemia. headache. hypotension. jaundice. movement disorders. muscle spasms. nightmare. palpitations. photosensitivity reaction. urinary retention. vision blurred SIDE-EFFECTS, FURTHER INFORMATION Elderly patients are more susceptible to anticholinergic side-effects. In children paradoxical stimulation may occur, especially with high doses.

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Pregnancy

Most manufacturers of antihistamines advise avoiding their use during pregnancy; however, there is no evidence of teratogenicity. Use in the latter part of the third trimester may cause adverse effects in neonates such as irritability, paradoxical excitability, and tremor.

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Breast Feeding

Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.

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Hepatic Impairment

Manufacturer advises caution.

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Renal Impairment

Use with caution.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 2 ▶Avomine (Manx Healthcare Ltd) Promethazine teoclate 25 mg Avomine 25mg tablets | 10 tablet p £1.13 | 28 tablet p £3.13 DT = £3.13 ▶Vertigon (Manx Healthcare Ltd) Promethazine teoclate 25 mg Vertigon 25mg tablets | 28 tablet p s DT = £3.13 ANTIMUSCARINICS eiiii F 820

PDF page 480

Clinical care

Patient And Carer Advice

Driving and skilled tasks Drowsiness may affect performance of skilled tasks (e.g. cycling or driving); sedating effects enhanced by alcohol.

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Dose text by age group

Child 5–9 years

12.5–37.5 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Child 10–17 years

25–75 mg daily; maximum 100 mg

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Adult

25–75 mg daily; maximum 100 mg per day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Child 5–9 years

12.5 mg once daily, dose to be taken at

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Child 10–17 years

25 mg once daily, dose to be taken at

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Adult

25 mg once daily, dose to be taken at bedtime on

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Child 5–9 years

12.5 mg, dose to be taken at onset of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Child 10–17 years

25 mg, dose to be taken at onset of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Adult

25 mg, dose to be taken at onset of motion

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Promethazine teoclate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 480

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 480

Cautions

PDF page 480

Safety

Important Safety Information

MHRA/CHM ADVICE: OVER-THE-COUNTER COUGH AND COLD MEDICINES FOR CHILDREN (APRIL 2009) Children under 6 years should not be given over-the- counter cough and cold medicines containing promethazine.

PDF page 480

Interactions

→Appendix 1: antihistamines, sedating

PDF page 480

Side Effects

PDF page 480

Pregnancy

PDF page 480

Breast Feeding

Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.

PDF page 480

Hepatic Impairment

Manufacturer advises caution.

PDF page 480

Renal Impairment

Use with caution.

PDF page 480

Dose and formulations

Medicinal Forms

PDF page 480

Clinical care

Patient And Carer Advice

Driving and skilled tasks Drowsiness may affect performance of skilled tasks (e.g. cycling or driving); sedating effects enhanced by alcohol.

PDF page 480

Dose text by age group

Child 5–9 years

12.5–37.5 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Child 10–17 years

25–75 mg daily; maximum 100 mg

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Adult

25–75 mg daily; maximum 100 mg per day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Child 5–9 years

12.5 mg once daily, dose to be taken at

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Child 10–17 years

25 mg once daily, dose to be taken at

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Adult

25 mg once daily, dose to be taken at bedtime on

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Child 5–9 years

12.5 mg, dose to be taken at onset of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Child 10–17 years

25 mg, dose to be taken at onset of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Adult

25 mg, dose to be taken at onset of motion

First-line fragment. Read the complete Indications and Dose section above.

PDF page 480

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.