Drug reference

Propranolol hydrochloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 184, 185

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Thyrotoxicosis (adjunct) ▶BY MOUTH ▶Adult: 10–40 mg 3–4 times a day Thyrotoxic crisis ▶BY INTRAVENOUS INJECTION ▶Adult: 1 mg, to be given over 1 minute, dose may be repeated if necessary at intervals of 2 minutes, maximum total dose is 5 mg in anaesthesia; maximum 10 mg per course Hypertension ▶BY MOUTH ▶Adult: Initially 80 mg twice daily, dose should be increased at weekly intervals as required; maintenance 160–320 mg daily Prophylaxis of variceal bleeding in portal hypertension ▶BY MOUTH ▶Adult: Initially 40 mg twice daily, then increased to 80 mg twice daily (max. per dose 160 mg twice daily), dose to be adjusted according to heart rate Phaeochromocytoma (only with an alpha-blocker) in preparation for surgery ▶BY MOUTH ▶Adult: 60 mg daily for 3 days before surgery Phaeochromocytoma (only with an alpha-blocker) in patients unsuitable for surgery ▶BY MOUTH ▶Adult: 30 mg daily Angina ▶BY MOUTH ▶Adult: Initially 40 mg 2–3 times a day; maintenance 120–240 mg daily Hypertrophic cardiomyopathy | Anxiety tachycardia ▶BY MOUTH ▶Adult: 10–40 mg 3–4 times a day Anxiety with symptoms such as palpitation, sweating and tremor ▶BY MOUTH ▶Adult: 40 mg once daily, then increased if necessary to 40 mg 3 times a day Prophylaxis after myocardial infarction ▶BY MOUTH ▶Adult: Initially 40 mg 4 times a day for 2–3 days, then 80 mg twice daily, start treatment 5 to 21 days after infarction Essential tremor ▶BY MOUTH ▶Adult: Initially 40 mg 2–3 times a day; maintenance 80–160 mg daily Migraine prophylaxis ▶BY MOUTH ▶Adult: 80–240 mg daily in divided doses Arrhythmias ▶BY MOUTH ▶Adult: 10–40 mg 3–4 times a day ▶BY INTRAVENOUS INJECTION ▶Adult: 1 mg, to be given over 1 minute, dose may be repeated if necessary at intervals of 2 minutes, maximum 10 mg per course (5 mg in anaesthesia)

PDF page 184

Prescribing And Dispensing Information

Modiﬁed- release preparations can be used for once daily administration.

PDF page 184

Safety

Important Safety Information

SAFE PRACTICE Propranolol has been confused with prednisolone; care must be taken to ensure the correct drug is prescribed and dispensed.

PDF page 184

Interactions

→Appendix 1: beta blockers, non-selective

PDF page 184

Side Effects

▶Rare or very rare Alopecia. memory loss. mood altered. neuromuscular dysfunction. postural hypotension. psychosis. skin reactions. thrombocytopenia ▶Frequency not known Hypoglycaemia Overdose Severe overdosages with propranolol may cause cardiovascular collapse, CNS depression, and convulsions.

PDF page 184

Hepatic Impairment

Manufacturer advises caution (increased risk of hepatic encephalopathy; risk of increased half-life). Dose adjustments ▶With oral use Manufacturer advises consider dose reduction.

PDF page 184

Renal Impairment

Dose adjustments Manufacturer advises caution; dose reduction may be required.

PDF page 184

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Oral solution CAUTIONARY AND ADVISORY LABELS 8 ▶Propranolol hydrochloride (Non-proprietary) Propranolol hydrochloride 1 mg per 1 ml Propranolol 5mg/5ml oral solution sugar-free | 150 ml P £23.51 DT = £23.51 Propranolol hydrochloride 2 mg per 1 ml Propranolol 10mg/5ml oral solution sugar-free | 150 ml P £28.45 DT = £28.45 Propranolol hydrochloride 8 mg per 1 ml Propranolol 40mg/5ml oral solution sugar-free | 150 ml P £36.51 DT = £36.51 Propranolol hydrochloride 10 mg per 1 ml Propranolol 50mg/5ml oral solution sugar-free | 150 ml P £38.51 DT = £38.51 Modified-release capsule CAUTIONARY AND ADVISORY LABELS 8, 25 ▶Bedranol SR (Sandoz Ltd, Almus Pharmaceuticals Ltd) Propranolol hydrochloride 80 mg Bedranol SR 80mg capsules | 28 capsule P £4.16 DT = £4.95 Propranolol hydrochloride 160 mg Bedranol SR 160mg capsules | 28 capsule P £4.59–£5.09 DT = £4.88 ▶Beta-Prograne (Actavis UK Ltd,Teva UK Ltd,Tillomed Laboratories Ltd) Propranolol hydrochloride 160 mg Beta-Prograne 160mg modified-release capsules | 28 capsule P £4.88–£6.11 DT = £4.88 ▶Half Beta-Prograne (Actavis UK Ltd,Tillomed Laboratories Ltd,Teva UK Ltd) Propranolol hydrochloride 80 mg Half Beta-Prograne 80mg modified-release capsules | 28 capsule P £4.95 DT = £4.95 Tablet CAUTIONARY AND ADVISORY LABELS 8 ▶Propranolol hydrochloride (Non-proprietary) Propranolol hydrochloride 10 mg Angilol 10mg tablets | 28 tablet P £1.05 DT = £1.97 Propranolol 10mg tablets | 28 tablet P £7.00 DT = £1.97 Propranolol hydrochloride 40 mg Propranolol 40mg tablets | 28 tablet P £7.00 DT = £2.07 Angilol 40mg tablets | 28 tablet P £0.94 DT = £2.07 Propranolol hydrochloride 80 mg Angilol 80mg tablets | 56 tablet P £1.15 DT = £2.54 Propranolol 80mg tablets | 56 tablet P £5.23 DT = £2.54 Propranolol hydrochloride 160 mg Propranolol 160mg tablets | 56 tablet P £5.88 DT = £5.88 ▶Bedranol (Ennogen Pharma Ltd) Propranolol hydrochloride 10 mg Bedranol 10mg tablets | 28 tablet P £1.54 DT = £1.97 Propranolol hydrochloride 40 mg Bedranol 40mg tablets | 28 tablet P £1.38 DT = £2.07 Propranolol hydrochloride 80 mg Bedranol 80mg tablets | 56 tablet P £0.95 DT = £2.54 Propranolol hydrochloride 160 mg Bedranol 160mg tablets | 56 tablet P £4.70 DT = £5.88 eiiii F 159

PDF pages 184, 185

Dose text by age group

Adult

10–40 mg 3–4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

1 mg, to be given over 1 minute, dose may be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

Initially 80 mg twice daily, dose should be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

Initially 40 mg twice daily, then increased to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

60 mg daily for 3 days before surgery

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

30 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

Initially 40 mg 2–3 times a day; maintenance

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

10–40 mg 3–4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

40 mg once daily, then increased if necessary to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

Initially 40 mg 4 times a day for 2–3 days, then

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

Initially 40 mg 2–3 times a day; maintenance

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

80–240 mg daily in divided doses

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

10–40 mg 3–4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

1 mg, to be given over 1 minute, dose may be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Propranolol hydrochloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 184, 185

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 184

Prescribing And Dispensing Information

Modiﬁed- release preparations can be used for once daily administration.

PDF page 184

Safety

Important Safety Information

SAFE PRACTICE Propranolol has been confused with prednisolone; care must be taken to ensure the correct drug is prescribed and dispensed.

PDF page 184

Interactions

→Appendix 1: beta blockers, non-selective

PDF page 184

Side Effects

PDF page 184

Hepatic Impairment

Manufacturer advises caution (increased risk of hepatic encephalopathy; risk of increased half-life). Dose adjustments ▶With oral use Manufacturer advises consider dose reduction.

PDF page 184

Renal Impairment

Dose adjustments Manufacturer advises caution; dose reduction may be required.

PDF page 184

Dose and formulations

Medicinal Forms

PDF pages 184, 185

Dose text by age group

Adult

10–40 mg 3–4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

1 mg, to be given over 1 minute, dose may be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

Initially 80 mg twice daily, dose should be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

Initially 40 mg twice daily, then increased to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

60 mg daily for 3 days before surgery

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

30 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

Initially 40 mg 2–3 times a day; maintenance

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

10–40 mg 3–4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

40 mg once daily, then increased if necessary to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

Initially 40 mg 4 times a day for 2–3 days, then

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

Initially 40 mg 2–3 times a day; maintenance

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

80–240 mg daily in divided doses

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

10–40 mg 3–4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Adult

1 mg, to be given over 1 minute, dose may be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 184

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.