Drug Action
Pyridostigmine bromide has weaker muscarinic action than neostigmine.
PDF page 1210
Loading InternPractice…
Drug reference
Pyridostigmine bromide has weaker muscarinic action than neostigmine.
PDF page 1210
Myasthenia gravis ▶INITIALLY BY MOUTH ▶Adult: 30–120 mg, doses to be given at suitable intervals throughout day; (by mouth) usual dose 0.3–1.2 g daily in divided doses, it is inadvisable to exceed a total daily dose of 450 mg in order to avoid acetylcholine receptor down-regulation; patients requiring doses exceeding 450 mg daily will usually require input from a specialised neuromuscular service. Immunosuppressant therapy is usually considered if the dose of pyridostigmine exceeds 360 mg daily
PDF page 1210
→Appendix 1: pyridostigmine
PDF page 1210
Gastrointestinal hypermotility. muscle cramps. rash
PDF page 1210
Dose adjustments Reduce dose; excreted by kidney.
PDF page 1210
There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: tablet, oral suspension, oral solution Tablet ▶Pyridostigmine bromide (Non-proprietary) Pyridostigmine bromide 60 mg Pyridostigmine bromide 60mg tablets | 200 tablet P £45.48 DT = £41.75 ▶Mestinon (Mylan) Pyridostigmine bromide 60 mg Mestinon 60mg tablets | 200 tablet P £45.57 DT = £41.75 CHOLINERGIC RECEPTOR STIMULATING DRUGS
PDF page 1210
30–120 mg, doses to be given at suitable
First-line fragment. Read the complete Indications and Dose section above.
PDF page 1210