Therapeutic Action
Vitamin
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Drug reference
Vitamin
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Prevention and treatment of isoniazid-induced peripheral neuropathy
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No contra-indication. May cause: peripheral neuropathy in the event of prolonged use with doses ≥ 200 mg daily. Pregnancy: no contra-indication Breast-feeding: no contra-indication
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25 mg tablet Also comes in 10 mg and 50 mg tablets.
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Prevention of isoniazid neuropathy Child under 5 kg: 5 mg once daily Child over 5 kg and adult: 10 mg once daily Treatment of isoniazid neuropathy Child: 50 mg once daily Adult: 50 mg 3 times daily
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Prevention: as long as treatment with isoniazid continues. Treatment: according to clinical response (in general, ≤ 3 weeks) then, preventive dose, as long as treatment with isoniazid continues.
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In children receiving isoniazid prophylaxis or treatment for tuberculosis: concomitant administration of pyridoxine at preventive dosage is recommended for children under 5 years and all children infected with HIV. Pyridoxine is also used for the prevention and treatment of cycloserin-induced neuropathy (150 to 200 mg daily in adults, in divided doses).
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– Below 25 °C
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10 mg once daily
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50 mg 3 times daily
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