Therapeutic Action
Antiprotozoal
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Drug reference
Antiprotozoal
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Treatment and secondary prophylaxis of toxoplasmosis in immunodeficient patients, in combination with sulfadiazine or clindamycin Primary prophylaxis of toxoplasmosis in immunodeficient patients, in combination with dapsone (only if co-trimoxazole cannot be used) Second-line treatment of isosporiasis in immunodeficient patients (only if co-trimoxazole cannot be used)
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Do not administer to patients with severe renal or hepatic impairment. May cause: gastrointestinal disturbances, seizures, leucopenia, thrombocytopenia, megaloblastic anaemia due to folic acid deficiency. Administer calcium folinate to prevent folic acid deficiency. Avoid if possible combination with other folate antagonists: co-trimoxazole, methotrexate (increased risk of folic acid deficiency). Monitor combination with zidovudine (increased risk of zidovudine-associated haematotoxicity). Pregnancy: CONTRA-INDICATED during the first trimester Breast-feeding: no contra-indication; however avoid concomitant administration of other folate antagonists.
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25 mg tablet
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Treatment of toxoplasmosis Adult: 2 doses of 100 mg on D1, then 75 to 100 mg once daily for at least 6 weeks Secondary prophylaxis of toxoplasmosis Adult: 25 to 50 mg once daily, as long as necessary Primary prophylaxis of toxoplasmosis Adult: 50 to 75 mg once weekly, as long as necessary Treatment of isosporiasis Adult: 50 to 75 mg once daily for 10 days
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The combination of sulfadoxine/pyrimethamine is used for the treatment of uncomplicated falciparum malaria.
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Below 25 °C
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2 doses of 100 mg on D1, then 75 to 100 mg once daily for at least 6 weeks
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25 to 50 mg once daily, as long as necessary
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50 to 75 mg once weekly, as long as necessary
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50 to 75 mg once daily for 10 days
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