Therapeutic Action
Antimalarial
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Drug reference
Antimalarial
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Treatment of uncomplicated falciparum malaria, when artemisinin-based combinations cannot be used Completion treatment following parenteral therapy with quinine for severe falciparum malaria, when artemisinin-based combinations cannot be used
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May cause: headache, skin rash; visual, auditory and gastrointestinal disturbances. Do not exceed indicated doses: risk of toxicity in the event of overdose. Avoid combination with drugs that prolong QT interval: amiodarone, other antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc. If the patient vomits within 30 minutes after administration, re-administer the full dose. If the patient vomits between 30 minutes and 1 hour after administration, re-administer half of the dose. Pregnancy: no contra-indication; it is recommended to administer quinine in combination with clindamycin if possible. Breast-feeding: no contra-indication
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300 mg quinine sulfate tablet
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Dosage is expressed in terms of salt. Except for quinine bisulfate, the dosage is the same for all quinine salts (sulfate, hydrochloride, dihydrochloride): Child and adult < 50 kg: 10 mg/kg 3 times daily at 8-hour intervals for 7 days Adult ≥ 50 kg: 600 mg 3 times daily at 8-hour intervals for 7 days Age Weight 300 mg tablet 5 months to < 2 years 7 to < 12 kg ¼ tab x 3 2 to < 8 years 12 to < 25 kg ½ tab x 3 8 to < 11 years 25 to < 35 kg 1 tab x 3 11 to < 14 years 35 to < 50 kg 1½ tab x 3 ≥ 14 years ≥ 50 kg 2 tab x 3
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10 mg of quinine sulfate or hydrochloride or dihydrochloride = 8 mg of quinine base; 14 mg of quinine bisulfate = 8 mg of quinine base.
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– Below 25 °C
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10 mg/kg 3 times daily at 8-hour intervals for 7 days
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