Drug reference

Raltitrexed

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1011, 1012

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Raltitrexed is a thymidylate synthase inhibitor.

PDF page 1011

Indications And Dose

Palliation of advanced colorectal cancer when fluorouracil and folinic acid cannot be used ▶BY INTRAVENOUS INFUSION ▶Adult: (consult local protocol)

PDF page 1011

National Funding Access Decisions

NICE decisions ▶Irinotecan, oxaliplatin, and raltitrexed for advanced colorectal cancer (August 2005) NICE TA93 Raltitrexed is not recommended for the treatment of advanced colorectal cancer. Its use should be conﬁned to clinical studies. www.nice.org.uk/TA93

PDF page 1011

Safety

Interactions

→Appendix 1: raltitrexed

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Side Effects

▶Common or very common Alopecia. anaemia. appetite decreased. arthralgia. asthenia. cellulitis. conjunctivitis. constipation. dehydration. diarrhoea. fever. gastrointestinal discomfort. headache. hyperbilirubinaemia. hyperhidrosis. inﬂuenza like illness. leucopenia. malaise. mucositis. muscle cramps. muscle tone increased. nausea. neutropenia. oral disorders. pain . peripheral oedema. sepsis. skin reactions. taste altered. thrombocytopenia. vomiting. weight decreased ▶Frequency not known Gastrointestinal haemorrhage

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Conception And Contraception

Ensure effective contraception during and for at least 6 months after treatment in men or women.

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Pregnancy

See Pregnancy and reproductive function in Cytotoxic drugs p. 938.

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Breast Feeding

Discontinue breast-feeding.

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Hepatic Impairment

Manufacture advises caution in mild to moderate impairment; avoid in severe impairment, jaundice or decompensated disease (no information available).

PDF page 1011

Renal Impairment

Avoid if creatinine clearance less than 25 mL/minute. Dose adjustments Reduce dose and increase dosing interval if creatinine clearance less than 65 mL/minute (consult product literature).

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Powder for solution for infusion ▶Tomudex (Pfizer Ltd) Raltitrexed 2 mg Tomudex 2mg powder for solution for infusion vials | 1 vial P £148.75 (Hospital only) RETINOID AND RELATED DRUGS

PDF page 1012

Dose text by age group

Adult

(consult local protocol)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1011

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Raltitrexed

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1011, 1012

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Raltitrexed is a thymidylate synthase inhibitor.

PDF page 1011

Indications And Dose

Palliation of advanced colorectal cancer when fluorouracil and folinic acid cannot be used ▶BY INTRAVENOUS INFUSION ▶Adult: (consult local protocol)

PDF page 1011

National Funding Access Decisions

PDF page 1011

Safety

Interactions

→Appendix 1: raltitrexed

PDF page 1011

Side Effects

PDF page 1011

Conception And Contraception

Ensure effective contraception during and for at least 6 months after treatment in men or women.

PDF page 1011

Pregnancy

See Pregnancy and reproductive function in Cytotoxic drugs p. 938.

PDF page 1011

Breast Feeding

Discontinue breast-feeding.

PDF page 1011

Hepatic Impairment

Manufacture advises caution in mild to moderate impairment; avoid in severe impairment, jaundice or decompensated disease (no information available).

PDF page 1011

Renal Impairment

Avoid if creatinine clearance less than 25 mL/minute. Dose adjustments Reduce dose and increase dosing interval if creatinine clearance less than 65 mL/minute (consult product literature).

PDF page 1011

Dose and formulations

Medicinal Forms

PDF page 1012

Dose text by age group

Adult

(consult local protocol)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1011

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.