Drug reference
As adjunctive therapy in the treatment of stable angina in patients inadequately controlled or intolerant of first- line antianginal therapies ▶BY MOUTH ▶Adult: Initially 375 mg twice daily for 2–4 weeks, then increased to 500 mg twice daily, then adjusted according to response to 750 mg twice daily; reduced if not tolerated to 375–500 mg twice daily
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Body-weight less than 60 kg. elderly. moderate to severe congestive heart failure. QT interval prolongation
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Scottish Medicines Consortium (SMC) decisions The Scottish Medicines Consortium has advised (November 2012) that ranolazine (Ranexa ®) is not recommended for use within NHS Scotland.
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→Appendix 1: ranolazine
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▶Common or very common Asthenia. constipation. headache. vomiting ▶Uncommon Anxiety. appetite decreased. confusion. cough. dehydration. dizziness postural. drowsiness. dry mouth. gastrointestinal discomfort. gastrointestinal disorders. haemorrhage. hallucination. hot flush. hypotension. insomnia. joint swelling. muscle cramps. muscle weakness. pain in extremity. peripheral oedema. QT interval prolongation. sensation abnormal. skin reactions. syncope. tinnitus. tremor. urinary disorders. urine discolouration. vertigo. vision disorders. weight decreased ▶Rare or very rare Acute kidney injury. altered smell sensation. angioedema. consciousness impaired. coordination abnormal. erectile dysfunction. gait abnormal. hearing impairment. hyponatraemia. memory loss. oral hypoaesthesia. pancreatitis. peripheral coldness
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Manufacturer advises avoid unless essential—no information available.
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Manufacturer advises avoid—no information available.
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Manufacturer advises caution in mild impairment; avoid in moderate to severe impairment (risk of increased exposure). Dose adjustments Manufacturer advises careful dose titration in mild impairment.
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Use with caution if eGFR 30–80 mL/minute/1.73 m2; avoid if eGFR less than 30 mL/minute/1.73 m2.
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There can be variation in the licensing of different medicines containing the same drug. Modified-release tablet CAUTIONARY AND ADVISORY LABELS 25 ▶Ranexa (A. Menarini Farmaceutica Internazionale SRL) Ranolazine 375 mg Ranexa 375mg modified-release tablets | 60 tablet P £48.98 DT = £48.98 Ranolazine 500 mg Ranexa 500mg modified-release tablets | 60 tablet P £48.98 DT = £48.98 Ranolazine 750 mg Ranexa 750mg modified-release tablets | 60 tablet P £48.98 DT = £48.98 SELECTIVE SINUS NODE IF INHIBITORS
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Patient alert card to be provided.
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Initially 375 mg twice daily for 2–4 weeks, then
First-line fragment. Read the complete Indications and Dose section above.
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