Names and pronunciation
(rav′-yoo-liz′-yoo-mab) Ultomiris
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Drug reference
(rav′-yoo-liz′-yoo-mab) Ultomiris
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Func. class.: Monoclonal antibody
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USES: Atypical hemolytic uremic syndrome in adults and pediatrics, paroxysmal nocturnal hemoglobinuria
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CONTRAINDICATIONS Hypersensitivity
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Black Box Warning: Meningococcal in- fection
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DOSAGE AND ROUTES Treat for at least 6 months • Adults ≥ 100 kg: IV 3,000 mg load, then 3,600 mg q8wk starting 2 wk after loading dose • Adults 60 to 99 kg: IV 2,700 mg load, then 3,300 mg q8wk starting 2 wk after loading dose • Adults 40 to 59 kg: IV 2,400 mg load, then 3,000 mg q8wk starting 2 wk after loading dose • Adolescents ≥ 100 kg: IV 3,000 mg load, then 3,600 mg q8wk starting 2 wk after the loading dose • Children and adolescents 60 to 99 kg: IV 2,700 mg load, then 3,300 mg q8wk start- ing 2 wk after loading dose • Children and adolescents 40 to 59 kg: IV 2,400 mg load, then 3,000 mg q8wk start- ing 2 wk after loading dose • Children and adolescents 30 to 39 kg: IV 1,200 mg load, then 2,700 mg q8wk start- ing 2 wk after loading dose • Children 20 to 29 kg: IV 900 mg load, then 2,100 mg q8wk starting 2 wk after the loading dose • Infants and children 10 to 19 kg: IV 600 mg load, then 600 mg q4wk starting 2 wk after loading dose • Infants and children 5 to 9 kg: IV 600 mg load, then 300 mg q4wk starting 2 wk after loading dose R
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Available forms: Injection 300 mg/30 mL single-dose vial HIGH ALERT
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• Children and adolescents 60 to 99 kg: IV 2,700 mg load, then 3,300 mg q8wk start- ing 2 wk after loading dose
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• Children and adolescents 40 to 59 kg: IV 2,400 mg load, then 3,000 mg q8wk start- ing 2 wk after loading dose
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• Children and adolescents 30 to 39 kg: IV 1,200 mg load, then 2,700 mg q8wk start- ing 2 wk after loading dose
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• Children 20 to 29 kg: IV 900 mg load, then 2,100 mg q8wk starting 2 wk after the loading dose
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• Infants and children 10 to 19 kg: IV 600 mg load, then 600 mg q4wk starting 2 wk after loading dose
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• Infants and children 5 to 9 kg: IV 600 mg load, then 300 mg q4wk starting 2 wk after loading dose R
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