Drug Action
Repaglinide stimulates insulin secretion.
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Drug reference
Repaglinide stimulates insulin secretion.
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Type 2 diabetes mellitus (as monotherapy or in combination with metformin when metformin alone inadequate) ▶BY MOUTH ▶Adult: Initially 500 micrograms (max. per dose 4 mg), Endocrine system adjusted according to response, dose to be taken within 30 minutes before main meals and adjusted at intervals of 1–2 weeks; maximum 16 mg per day Type 2 diabetes mellitus (as monotherapy or in combination with metformin when metformin alone inadequate), if transferring from another oral antidiabetic drug ▶BY MOUTH ▶Adult: Initially 1 mg (max. per dose 4 mg), adjusted according to response, dose to be taken within 30 minutes before main meals and adjusted at intervals of 1–2 weeks; maximum 16 mg per day
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Ketoacidosis
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Debilitated patients. elderly (no information available). malnourished patients CAUTIONS, FURTHER INFORMATION Manufacturer advises patients exposed to stress (including fever, trauma, infection or surgery) may require treatment interruption and temporary replacement with insulin to maintain glycaemic control.
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→Appendix 1: repaglinide
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▶Common or very common Abdominal pain. diarrhoea. hypoglycaemia ▶Rare or very rare Cardiovascular disease. constipation. hepatic function abnormal. vasculitis. vision disorders. vomiting ▶Frequency not known Acute coronary syndrome. hypoglycaemic coma. nausea. skin reactions
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Avoid.
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Avoid—present in milk in animal studies.
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Manufacturer advises avoid in severe impairment (risk of increased exposure).
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Use with caution.
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There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Repaglinide (Non-proprietary) Repaglinide 500 microgram Repaglinide 500microgram tablets | 30 tablet P £2.30–£3.33 | 90 tablet P £10.00 DT = £6.91 Repaglinide 1 mg Repaglinide 1mg tablets | 30 tablet P £2.62– £3.53 | 90 tablet P £10.58 DT = £7.87 Repaglinide 2 mg Repaglinide 2mg tablets | 90 tablet P £10.50 DT = £4.72 ▶Enyglid (Consilient Health Ltd) Repaglinide 500 microgram Enyglid 0.5mg tablets | 30 tablet P £3.33 | 90 tablet P £9.99 DT = £6.91 Repaglinide 1 mg Enyglid 1mg tablets | 30 tablet P £3.33 | 90 tablet P £9.99 DT = £7.87 Repaglinide 2 mg Enyglid 2mg tablets | 90 tablet P £9.99 DT = £4.72 ▶Prandin (Novo Nordisk Ltd) Repaglinide 500 microgram Prandin 0.5mg tablets | 30 tablet P £3.92 Repaglinide 1 mg Prandin 1mg tablets | 30 tablet P £3.92 Repaglinide 2 mg Prandin 2mg tablets | 90 tablet P £11.76 DT = £4.72 BLOOD GLUCOSE LOWERING DRUGS › SODIUM GLUCOSE CO-TRANSPORTER 2 INHIBITORS
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Driving and skilled tasks Drivers need to be particularly careful to avoid hypoglycaemia and should be warned of the problems.
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Initially 500 micrograms (max. per dose 4 mg),
First-line fragment. Read the complete Indications and Dose section above.
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Initially 1 mg (max. per dose 4 mg), adjusted
First-line fragment. Read the complete Indications and Dose section above.
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