Names and pronunciation
(rye′boh-flay-vin)
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Drug reference
(rye′boh-flay-vin)
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Func. class.: Vit B2, water soluble
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ACTION: Needed for respiratory reactions by catalyzing proteins
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USES: Vit B2 deficiency or polyneuritis; cheilosis adjunct with thiamine
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Unlabeled uses: Migraine prophylaxis
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CONTRAINDICATIONS None known Precautions: Pregnancy
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SIDE EFFECTS GU: Yellow discoloration of urine
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INTERACTIONS Increase: riboflavin need—alcohol, pro- benecid, tricyclics, phenothiazines Decrease: action of tetracyclines Drug/Lab Test • May cause false elevations of urinary catecholamines
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DOSAGE AND ROUTES Deficiency • Adult: PO 5-30 mg/day • Child ≥12 yr: PO 3-10 mg/day, then 0.6 mg/1000 calories ingested RDA • Adult: PO (males) 1.3 mg, (females) 1.1 mg
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Available forms: Tabs 5, 10, 25, 50, 100, 250 mg
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Administer: • With food for better absorption • Store in airtight, light-resistant container
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Assess: • Nutritional status: liver, eggs, dairy products, yeast, whole grains, green veg- etables
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Evaluate: • Therapeutic response: absence of headache, GI problems, cheilosis, skin lesions, depression; burning, itchy eyes; anemia
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: • That urine may turn bright yellow • About the addition of needed foods rich in riboflavin • To avoid alcohol
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PHARMACOKINETICS Half-life 65-85 min, 60% protein bound, unused amounts excreted in urine (unchanged)
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• Adult: PO 5-30 mg/day
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• Child ≥12 yr: PO 3-10 mg/day, then 0.6 mg/1000 calories ingested RDA
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• Adult: PO (males) 1.3 mg, (females) 1.1 mg
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