Indications And Dose
Brucellosis in combination with other antibacterials | Legionnaires disease in combination with other antibacterials | Serious staphylococcal infections in combination with other antibacterials ▶BY MOUTH, OR BY INTRAVENOUS INFUSION ▶Child 1–11 months: 5–10 mg/kg twice daily ▶Child 1–17 years: 10 mg/kg twice daily (max. per dose 600 mg) ▶Adult: 0.6–1.2 g daily in 2–4 divided doses Endocarditis in combination with other drugs ▶BY MOUTH, OR BY INTRAVENOUS INFUSION ▶Adult: 0.6–1.2 g daily in 2–4 divided doses Tuberculosis, in combination with other drugs (intermittent supervised 6-month treatment) (under expert supervision) ▶BY MOUTH ▶Child: 15 mg/kg 3 times a week (max. per dose 900 mg) for 6 months (initial and continuation phases) ▶Adult: 600–900 mg 3 times a week for 6 months (initial continued → and continuation phases) Tuberculosis, in combination with other drugs (standard unsupervised 6-month treatment) ▶BY MOUTH ▶Child (body-weight up to 50 kg): 15 mg/kg once daily for 6 months (initial and continuation phases); maximum 450 mg per day ▶Child (body-weight 50 kg and above): 15 mg/kg once daily for 6 months (initial and continuation phases); Infection maximum 600 mg per day ▶Adult (body-weight up to 50 kg): 450 mg once daily for 6 months (initial and continuation phases) ▶Adult (body-weight 50 kg and above): 600 mg once daily for 6 months (initial and continuation phases) Prevention of tuberculosis in susceptible close contacts or those who have become tuberculin positive, in combination with isoniazid ▶BY MOUTH ▶Child 1 month–11 years (body-weight up to 50 kg): 15 mg/kg daily for 3 months; maximum 450 mg per day ▶Child 1 month–11 years (body-weight 50 kg and above): 15 mg/kg daily for 3 months; maximum 600 mg per day ▶Child 12–17 years (body-weight up to 50 kg): 450 mg daily for 3 months ▶Child 12–17 years (body-weight 50 kg and above): 600 mg daily for 3 months ▶Adult (body-weight up to 50 kg): 450 mg daily for 3 months ▶Adult (body-weight 50 kg and above): 600 mg daily for 3 months Prevention of tuberculosis in susceptible close contacts or those who have become tuberculin positive, who are isoniazid-resistant ▶BY MOUTH ▶Child 1 month–11 years (body-weight up to 50 kg): 15 mg/kg daily for 6 months; maximum 450 mg per day ▶Child 1 month–11 years (body-weight 50 kg and above): 15 mg/kg daily for 6 months; maximum 600 mg per day ▶Child 12–17 years (body-weight up to 50 kg): 450 mg daily for 6 months ▶Child 12–17 years (body-weight 50 kg and above): 600 mg daily for 6 months Prevention of tuberculosis in susceptible close contacts or those who have become tuberculin positive, who are isoniazid-resistant and under 35 years ▶BY MOUTH ▶Adult 18–34 years (body-weight up to 50 kg): 450 mg daily for 6 months ▶Adult 18–34 years (body-weight 50 kg and above): 600 mg daily for 6 months Prevention of secondary case of Haemophilus influenzae type b disease ▶BY MOUTH ▶Child 1–2 months: 10 mg/kg once daily for 4 days ▶Child 3 months–11 years: 20 mg/kg once daily (max. per dose 600 mg) for 4 days ▶Child 12–17 years: 600 mg once daily for 4 days ▶Adult: 600 mg once daily for 4 days Prevention of secondary case of meningococcal meningitis ▶BY MOUTH ▶Child 1–11 months: 5 mg/kg every 12 hours for 2 days ▶Child 1–11 years: 10 mg/kg every 12 hours (max. per dose 600 mg), for 2 days ▶Child 12–17 years: 600 mg every 12 hours for 2 days ▶Adult: 600 mg every 12 hours for 2 days Multibacillary leprosy in combination with dapsone and clofazimine (3-drug regimen) | Paucibacillary leprosy in combination with dapsone (2-drug regimen) ▶BY MOUTH ▶Adult (body-weight up to 35 kg): 450 mg once a month, supervised administration ▶Adult (body-weight 35 kg and above): 600 mg once a month, supervised administration
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