Drug reference
HIV infection in combination with other antiretroviral drugs in patients not previously treated with antiretroviral therapy and if plasma HIV-1 RNA concentration less than or equal to 100 000 copies/mL ▶BY MOUTH ▶Adult: 25 mg once daily
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Acute porphyrias p. 1120
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→Appendix 1: rilpivirine
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▶Common or very common Appetite decreased. depression. dizziness. drowsiness. dry mouth. fatigue. gastrointestinal discomfort. headache. nausea. rash. sleep disorders. vomiting ▶Uncommon Immune reconstitution inflammatory syndrome Infection ▶Common or very common Abdominal pain. anaemia (may require transfusion). asthenia. diarrhoea. dizziness. headache. insomnia. nausea. neutropenia. skin reactions . vomiting ▶Uncommon Angioedema. lactic acidosis. pancreatitis ▶Frequency not known Immune reconstitution inflammatory syndrome. osteonecrosis SIDE-EFFECTS, FURTHER INFORMATION Osteonecrosis has been reported in patients with advanced HIV disease or following long-term exposure to combination antiretroviral therapy.
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Manufacturer advises avoid unless essential— no information available. Monitoring Mitochondrial dysfunction has been reported in infants exposed to nucleoside reverse transcriptase inhibitors in utero; the main effects include haematological, metabolic, and neurological disorders; all infants whose mothers received nucleoside reverse transcriptase inhibitors during pregnancy should be monitored for relevant signs or symptoms.
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Manufacturer advises caution in moderate impairment (limited information available); avoid in severe impairment (no information available). In general, manufacturers advise caution in patients with chronic hepatitis B or C (increased risk of hepatic side-effects). eiiii F 683
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Manufacturer advises caution in severe impairment.
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 3, 21, 25 ▶Edurant (Janssen-Cilag Ltd) Rilpivirine (as Rilpivirine hydrochloride) 25 mg Edurant 25mg tablets | 30 tablet P £200.27 Combinations available: Dolutegravir with rilpivirine, p. 679. Emtricitabine with rilpivirine and tenofovir alafenamide, p. 687. Emtricitabine with rilpivirine and tenofovir disoproxil, p. 688 ANTIVIRALS › NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS Nucleoside reverse f transcriptase inhibitors
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Patients or carers should be given advice on how to administer rilpivirine tablets. Missed doses If a dose is more than 12 hours late, the missed dose should not be taken and the next dose should be taken at the normal time.
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25 mg once daily
First-line fragment. Read the complete Indications and Dose section above.
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