Indications And Dose
To extend life in patients with amyotrophic lateral sclerosis, initiated by specialist experienced in the management of motor neurone disease ▶BY MOUTH ▶Adult: 50 mg twice daily
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Drug reference
To extend life in patients with amyotrophic lateral sclerosis, initiated by specialist experienced in the management of motor neurone disease ▶BY MOUTH ▶Adult: 50 mg twice daily
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Acute porphyrias p. 1120
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History of abnormal hepatic function (consult product literature for details). interstitial lung disease CAUTIONS, FURTHER INFORMATION ▶Interstitial lung disease Perform chest radiography if symptoms such as dry cough or dyspnoea develop; discontinue if interstitial lung disease is diagnosed.
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NICE decisions ▶Guidance on the use of Riluzole (Rilutek ®) for the treatment of Motor Neurone Disease (January 2001) NICE TA20 Riluzole is recommended for treating the amyotrophic lateral sclerosis (ALS) form of Motor Neurone Disease (MND). Treatment should be initiated by a specialist in MND but it can then be supervised under a shared-care arrangement involving the general practitioner. www.nice.org.uk/guidance/ta20
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→Appendix 1: riluzole
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▶Common or very common Abdominal pain. asthenia. diarrhoea. dizziness. drowsiness. headache. nausea. oral paraesthesia. pain. tachycardia. vomiting ▶Uncommon Anaemia. angioedema. interstitial lung disease. pancreatitis ▶Frequency not known Hepatitis. neutropenia SIDE-EFFECTS, FURTHER INFORMATION White blood cell counts should be determined in febrile illness; neutropenia requires discontinuation of riluzole.
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Avoid—no information available.
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Avoid—no information available.
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Manufacturer advises avoid (risk of increased exposure).
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Avoid—no information available.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution, powder Oral suspension ▶Teglutik (Martindale Pharmaceuticals Ltd) Riluzole 5 mg per 1 ml Teglutik 5mg/1ml oral suspension sugar-free | 300 ml P £100.00 DT = £100.00 Tablet ▶Riluzole (Non-proprietary) Riluzole 50 mg Riluzole 50mg tablets | 56 tablet P £320.00 DT = £22.42 ▶Rilutek (Sanofi) Riluzole 50 mg Rilutek 50mg tablets | 56 tablet P £320.33 DT = £22.42 3.1 Muscular dystrophy DRUGS FOR NEUROMUSCULAR DISORDERS
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Blood disorders Patients or their carers should be told how to recognise signs of neutropenia and advised to seek immediate medical attention if symptoms such as fever occur. Driving and skilled tasks Dizziness or vertigo may affect performance of skilled tasks (e.g. driving).
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50 mg twice daily
First-line fragment. Read the complete Indications and Dose section above.
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