Drug reference
HIV infection in combination with other antiretroviral drugs (high-dose ritonavir) ▶BY MOUTH ▶Adult: Initially 300 mg every 12 hours for 3 days, increased in steps of 100 mg every 12 hours over not longer than 14 days; increased to 600 mg every 12 hours Low-dose booster to increase effect of other protease inhibitors ▶BY MOUTH ▶Adult: 100–200 mg 1–2 times a day
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Cardiac conduction disorders. pancreatitis. structural heart disease
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→Appendix 1: HIV-protease inhibitors
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▶Common or very common Back pain. concentration impaired. confusion. cough. dehydration. feeling hot. flushing. gastrointestinal haemorrhage. gout. hypotension. menorrhagia. myopathy. oedema. oral paraesthesia. oropharyngeal pain. paraesthesia. peripheral coldness. pharyngitis. renal impairment. syncope. thrombocytopenia. urinary frequency increased. vision blurred ▶Uncommon Myocardial infarction ▶Rare or very rare Hyperglycaemia. toxic epidermal necrolysis SIDE-EFFECTS, FURTHER INFORMATION Signs and symptoms suggestive of pancreatitis (including raised serum lipase) should be evaluated — discontinue if pancreatitis diagnosed.
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Dose adjustments Only use low-dose booster to increase the effect of other protease inhibitors.
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When used as a low-dose booster, manufacturer advises caution in severe impairment; avoid in decompensated liver disease. When used in high-doses, manufacturer advises avoid in severe impairment. Dose adjustments Manufacturer advises consult product literature of co-administered protease inhibitor.
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 21, 25 ▶Ritonavir (Non-proprietary) Ritonavir 100 mg Ritonavir 100mg tablets | 30 tablet P £16.52– £19.44 | 30 tablet P £19.44 (Hospital only) ▶Norvir (AbbVie Ltd) Ritonavir 100 mg Norvir 100mg tablets | 30 tablet P £19.44 eiiii F 693
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Initially 300 mg every 12 hours for 3 days,
First-line fragment. Read the complete Indications and Dose section above.
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100–200 mg 1–2 times a day
First-line fragment. Read the complete Indications and Dose section above.
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