Drug reference
Treatment of acute migraine ▶BY MOUTH ▶Adult: 10 mg, dose to be taken as soon as possible after onset, followed by 10 mg after 2 hours if required, dose to be taken only if migraine recurs (patient not responding to initial dose should not take second dose for same attack); maximum 20 mg per day
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DUE TO INTERACTIONS ▶Manufacturer advises reduce dose to 5 mg with concurrent use of propranolol. l UNLICENSED USE Not licensed for use in elderly.
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Coronary vasospasm. ischaemic heart disease. peripheral vascular disease. previous cerebrovascular accident. previous myocardial infarction. previous transient ischaemic attack. Prinzmetal’s angina. severe hypertension. uncontrolled hypertension
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Conditions which predispose to coronary artery disease. elderly
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→Appendix 1: rizatriptan
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▶Common or very common Alertness decreased. asthenia. diarrhoea. dizziness. drowsiness. dry mouth. dyspepsia. feeling abnormal. headache. insomnia. musculoskeletal stiffness. nausea. pain. palpitations. sensation abnormal . throat complaints. vasodilation. vomiting ▶Uncommon Angioedema. arrhythmias. ataxia. disorientation. dyspnoea. face oedema. hyperhidrosis. hypertension. muscle weakness. myalgia. nervousness. skin reactions. syncope. taste altered. thirst. tongue swelling. tremor. vertigo. vision blurred ▶Rare or very rare Hypersensitivity. stroke. wheezing ▶Frequency not known Colitis ischaemic. myocardial infarction. myocardial ischaemia. peripheral vascular disease. seizure. serotonin syndrome. toxic epidermal necrolysis SIDE-EFFECTS, FURTHER INFORMATION Discontinue if symptoms of heat, heaviness, pressure or tightness (including throat and chest) occur.
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There is limited experience of using 5HT1- receptor agonists during pregnancy; manufacturers advise that they should be avoided unless the potential benefit outweighs the risk.
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Present in milk in animal studies— withhold breast-feeding for 24 hours.
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Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment (no information available). Dose adjustments Manufacturer advises dose reduction to 5 mg in mild to moderate impairment.
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Avoid in severe impairment. Dose adjustments Reduce dose to 5 mg in mild to moderate impairment.
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Rizatriptan orodispersible tablets should be placed on the tongue, allowed to disperse and swallowed. Rizatriptan oral lyophilisates should be placed on the tongue and allowed to dissolve.
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There can be variation in the licensing of different medicines containing the same drug. Orodispersible tablet CAUTIONARY AND ADVISORY LABELS 3 EXCIPIENTS: May contain Aspartame ▶Rizatriptan (Non-proprietary) Rizatriptan (as Rizatriptan benzoate) 5 mg Rizatriptan 5mg orodispersible tablets sugar-free | 3 tablet P s Rizatriptan (as Rizatriptan benzoate) 10 mg Rizatriptan 10mg orodispersible tablets sugar-free | 3 tablet P £13.37 DT = £4.79 sugar-free | 6 tablet P £8.88–£26.74 Tablet CAUTIONARY AND ADVISORY LABELS 3 ▶Rizatriptan (Non-proprietary) Rizatriptan (as Rizatriptan benzoate) 5 mg Rizatriptan 5mg tablets | 3 tablet P £13.37 | 6 tablet P £26.74 DT = £26.73 Rizatriptan (as Rizatriptan benzoate) 10 mg Rizatriptan 10mg tablets | 3 tablet P £13.37 DT = £3.20 | 6 tablet P £6.40– £26.74 ▶Maxalt (Merck Sharp & Dohme Ltd) Rizatriptan (as Rizatriptan benzoate) 5 mg Maxalt 5mg tablets | 6 tablet P £26.74 DT = £26.73 Rizatriptan (as Rizatriptan benzoate) 10 mg Maxalt 10mg tablets | 3 tablet P £13.37 DT = £3.20 | 6 tablet P £26.74 Oral lyophilisate CAUTIONARY AND ADVISORY LABELS 3 EXCIPIENTS: May contain Aspartame ▶Maxalt Melt (Merck Sharp & Dohme Ltd) Rizatriptan (as Rizatriptan benzoate) 10 mg Maxalt Melt 10mg oral lyophilisates sugar-free | 3 tablet P £13.37 DT = £13.37 sugar-free | 6 tablet P £26.74 DT = £26.74 sugar-free | 12 tablet P £53.48
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Patients or carers should be given advice on how to administer rizatriptan orodispersible tablets and oral lyophilisates. Driving and skilled tasks Drowsiness may affect performance of skilled tasks (e.g. driving).
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10 mg, dose to be taken as soon as possible after
First-line fragment. Read the complete Indications and Dose section above.
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