Names and pronunciation
(roe-la′pi-tant) Varubi
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Drug reference
(roe-la′pi-tant) Varubi
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Func. class.: Antiemetic
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USES: Prevention of delayed nausea and vomiting associated with emetogenic cancer chemotherapy, including but not limited to highly emetogenic chemotherapy (in combination with other antiemetic agents)
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CONTRAINDICATIONS Hypersensitivity, use with CYP2D6 sub- strates (thioridazine, pimozide); child <2 yr
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DOSAGE AND ROUTES Chemotherapy-induced nausea and vomiting (prevention) • Adult: PO 180 mg give within 2 hr before chemotherapy on day 1 only (in combination with dexamethasone given on days 1, 2, 3, and 4 and a 5-HT3 recep- tor antagonist given on day 1)
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Available forms: Emulsion for injection 165.5/92.5 mL; tablet 90 mg HIGH ALERT
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• Adult: PO 180 mg give within 2 hr before chemotherapy on day 1 only (in combination with dexamethasone given on days 1, 2, 3, and 4 and a 5-HT3 recep- tor antagonist given on day 1)
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