Indications And Dose
Parkinson’s disease, either used alone or as adjunct to co- beneldopa or co-careldopa ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 750 micrograms daily in 3 divided doses, Nervous system then increased in steps of 750 micrograms daily, dose to be increased at weekly intervals, increased to 3 mg daily in 3 divided doses, then increased in steps of 1.5–3 mg daily, adjusted according to response, dose to be increased at weekly intervals; usual dose 9–16 mg daily in 3 divided doses, higher doses may be required if used with levodopa, when administered as adjunct to levodopa, concurrent dose of levodopa may be reduced by approx. 20%, daily maximum dose to be given in 3 divided doses; maximum 24 mg per day ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: Initially 2 mg once daily for 1 week, then 4 mg once daily, increased in steps of 2 mg at intervals of at least 1 week, adjusted according to response, increased to up to 8 mg once daily, dose to be increased further if still no response; increased in steps of 2–4 mg at intervals of at least 2 weeks if required, consider slower titration in patients over 75 years, when administered as adjunct to levodopa, concurrent dose of levodopa may gradually be reduced by approx. 30%; maximum 24 mg per day Parkinson’s disease in patients transferring from ropinirole immediate-release tablets ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: Initially ropinirole modified-release once daily substituted for total daily dose equivalent of ropinirole immediate-release tablets; if control not maintained after switching, titrate dose as above Moderate to severe restless legs syndrome ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 250 micrograms once daily for 2 days, increased if tolerated to 500 micrograms once daily for 5 days, then increased if tolerated to 1 mg once daily for 7 days, then increased in steps of 500 micrograms daily, adjusted according to response, dose to be increased at weekly intervals; usual dose 2 mg once daily, doses to be taken at night; maximum 4 mg per day l UNLICENSED USE Doses in the BNF may differ from those in product literature.
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