Indications And Dose
Adjunctive treatment of seizures in Lennox-Gastaut syndrome without valproate (initiated by a specialist) ▶BY MOUTH ▶Child 1–3 years: Initially 5 mg/kg twice daily, then increased in steps of up to 5 mg/kg twice daily (max. per dose 22.5 mg/kg twice daily), adjusted according to response, dose to be increased at intervals of not less than 3 days to the target dose (maximum dose), each dose should be given to the nearest 0.5 mL ▶Child 4–17 years (body-weight up to 30 kg): Initially 100 mg twice daily, then increased in steps of 100 mg twice daily (max. per dose 500 mg twice daily), adjusted according to response, dose to be increased at intervals of not less than 3 days ▶Child 4–17 years (body-weight 30–50 kg): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 900 mg twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days ▶Child 4–17 years (body-weight 50.1–70 kg): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 1.2 g twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days ▶Child 4–17 years (body-weight 70.1 kg and above): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 1.6 g twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days ▶Adult (body-weight 30–50 kg): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 900 mg twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days ▶Adult (body-weight 50.1–70 kg): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 1.2 g twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days ▶Adult (body-weight 70.1 kg and above): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 1.6 g twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days Adjunctive treatment of seizures in Lennox-Gastaut syndrome with valproate (initiated by a specialist) ▶BY MOUTH ▶Child 1–3 years: Initially 5 mg/kg twice daily, then increased in steps of up to 5 mg/kg twice daily (max. per dose 15 mg/kg twice daily), adjusted according to response, dose to be increased at intervals of not less than 3 days to the target dose (maximum dose), each dose should be given to the nearest 0.5 mL ▶Child 4–17 years (body-weight up to 30 kg): Initially 100 mg twice daily, then increased in steps of 100 mg twice daily (max. per dose 300 mg twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days ▶Child 4–17 years (body-weight 30–50 kg): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 600 mg twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days ▶Child 4–17 years (body-weight 50.1–70 kg): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 800 mg twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days ▶Child 4–17 years (body-weight 70.1 kg and above): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 1.1 g twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days ▶Adult (body-weight 30–50 kg): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 600 mg twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days ▶Adult (body-weight 50.1–70 kg): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 800 mg twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days ▶Adult (body-weight 70.1 kg and above): Initially 200 mg twice daily, then increased in steps of 200 mg twice daily (max. per dose 1.1 g twice daily), adjusted according to response, dose to be increased at intervals of not less than 2 days
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