Drug reference

Rupatadine

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 318, 319

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Rupatadine is a second generation non- sedating antihistamine.

PDF page 318

Indications And Dose

Symptomatic relief of allergic rhinitis and urticaria ▶BY MOUTH USING TABLETS ▶Child 12–17 years: 10 mg once daily ▶Adult: 10 mg once daily

PDF page 318

Cautions

Elderly—limited information available. history of QT-interval prolongation. predisposition to arrhythmia . uncorrected hypokalaemia

PDF page 319

Safety

Interactions

→Appendix 1: antihistamines, non- sedating

PDF page 319

Side Effects

▶Common or very common Asthenia. dizziness. drowsiness. dry mouth. headache ▶Uncommon Appetite increased. arthralgia. back pain. concentration impaired. constipation. cough. diarrhoea. dry throat. eosinophilia (in children). epistaxis. fever. gastrointestinal discomfort. increased risk of infection. irritability. malaise. myalgia. nasal dryness. nausea. neutropenia (in children). night sweats (in children). oropharyngeal pain. skin reactions. thirst. vomiting. weight increased ▶Rare or very rare Palpitations. tachycardia SIDE-EFFECTS, FURTHER INFORMATION Non-sedating antihistamines such as rupatadine cause less sedation and psychomotor impairment than the older antihistamines, but can still occur; sedation is generally minimal. This is because non-sedating antihistamines penetrate the blood brain barrier to a much lesser extent.

PDF page 319

Pregnancy

Most manufacturers of antihistamines advise avoiding their use during pregnancy; however, there is no evidence of teratogenicity.

PDF page 319

Breast Feeding

Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.

PDF page 319

Hepatic Impairment

Manufacturer advises avoid (no information available).

PDF page 319

Renal Impairment

Manufacturer advises avoid—no information available.

PDF page 319

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Rupatadine (Non-proprietary) Rupatadine (as Rupatadine fumarate) 10 mg Rupatadine 10mg tablets | 30 tablet P £36.00 DT = £35.25 ANTIHISTAMINES › SEDATING

PDF page 319

Dose text by age group

Child 12–17 years

10 mg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 318

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Rupatadine

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 318, 319

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Rupatadine is a second generation non- sedating antihistamine.

PDF page 318

Indications And Dose

Symptomatic relief of allergic rhinitis and urticaria ▶BY MOUTH USING TABLETS ▶Child 12–17 years: 10 mg once daily ▶Adult: 10 mg once daily

PDF page 318

Cautions

Elderly—limited information available. history of QT-interval prolongation. predisposition to arrhythmia . uncorrected hypokalaemia

PDF page 319

Safety

Interactions

→Appendix 1: antihistamines, non- sedating

PDF page 319

Side Effects

PDF page 319

Pregnancy

Most manufacturers of antihistamines advise avoiding their use during pregnancy; however, there is no evidence of teratogenicity.

PDF page 319

Breast Feeding

Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.

PDF page 319

Hepatic Impairment

Manufacturer advises avoid (no information available).

PDF page 319

Renal Impairment

Manufacturer advises avoid—no information available.

PDF page 319

Dose and formulations

Medicinal Forms

PDF page 319

Dose text by age group

Child 12–17 years

10 mg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 318

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.