Names and pronunciation
(sak-ue′bi-tril/val-sar′tan) Entresto
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Drug reference
(sak-ue′bi-tril/val-sar′tan) Entresto
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Func. class.: Antihypertensive, angiotensin II receptor blocker, neprilysin inhibitor
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USES: Reduce the risk of cardiovas- cular death and hospitalization for heart failure (HF) in patients with chronic HF (New York Heart Associa- tion Class II-IV) and reduced ejection fraction; symptomatic HF with systemic left ventricular systolic dysfunction in child ≥1 yr
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CONTRAINDICATIONS Hypersensitivity to sacubitril, valsartan, or any component; use within 36 hr of ACE inhibitors; use with aliskiren in dia- betes, angioedema
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DOSAGE AND ROUTES Heart failure • Adult: Patients previously taking a moderate- to high-dose ACE inhibitor (>10 mg/day of enalapril or equiva- lent) or angiotensin II receptor blocker (>160 mg/day of valsartan or equivalent): PO Sacubitril 49 mg/valsar- tan 51 mg bid, double the dose after 2-4 wk to the target of sacubitril 97 mg/val- sartan 103 mg bid • Adult: Patients previously taking low doses of an ACE inhibitor (≤10 mg/day of enalapril or equivalent) or ARB (≤160 mg/day of valsartan or equivalent): PO Sacubitril 24 mg/valsar- tan 26 mg bid double the dose q2-4 wk to the target of sacubitril 97 mg/valsartan 103 mg bid • Adult: Patients not currently tak- ing an ACE inhibitor or an ARB: PO Sacubitril 24 mg/valsartan 26 mg bid, double the dose q2-4 wk to the target of sacubitril 97 mg/valsartan 103 mg bid Symptomatic HF with systemic left ventricular systolic dysfunction in child ≥1 yr • Child/adolescent <40 kg: PO solu- tion (extemporaneously prepared): Initial: 1.6 mg/kg/dose bid; titrate dose in 2 wk to 2.3 mg/kg/dose bid, then 2 wk later to 3.1 mg/kg/dose bid • Child/adolescent 40 to <50 kg: PO Tab- lets: Sacubitril 24 mg/valsartan 26 mg bid; titrate dose in 2 wk to sacubitril 49 mg/val- sartan 51 mg bid, then 2 wk later to sacubi- tril 72 mg/valsartan 78 mg (three 24/26-mg tablets) bid; ≥50 kg: sacubitril 49 mg/val- S sartan 51 mg bid; titrate dose in 2 wk to sacubitril 72 mg/valsartan 78 mg (three 24/26-mg tablets) bid, then 2 wk later to sacubitril 97 mg/valsartan 103 mg bid
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Available forms: Tabs 24/26, 49/51, 97/103 mg
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• Adult: Patients previously taking a moderate- to high-dose ACE inhibitor (>10 mg/day of enalapril or equiva- lent) or angiotensin II receptor blocker (>160 mg/day of valsartan or equivalent): PO Sacubitril 49 mg/valsar- tan 51 mg bid, double the dose after 2-4 wk to the target of sacubitril 97 mg/val- sartan 103 mg bid
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• Adult: Patients previously taking low doses of an ACE inhibitor (≤10 mg/day of enalapril or equivalent) or ARB (≤160 mg/day of valsartan or equivalent): PO Sacubitril 24 mg/valsar- tan 26 mg bid double the dose q2-4 wk to the target of sacubitril 97 mg/valsartan 103 mg bid
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• Adult: Patients not currently tak- ing an ACE inhibitor or an ARB: PO Sacubitril 24 mg/valsartan 26 mg bid, double the dose q2-4 wk to the target of sacubitril 97 mg/valsartan 103 mg bid Symptomatic HF with systemic left ventricular systolic dysfunction in child ≥1 yr
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