Drug Action
Safinamide is a monoamine-oxidase-B inhibitor.
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Drug reference
Safinamide is a monoamine-oxidase-B inhibitor.
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Parkinson’s disease, as an adjunct to levodopa alone or in combination with other antiparkinsonian drugs, for mid- to late-stage fluctuations ▶BY MOUTH ▶Adult: 50 mg once daily, increased if necessary to 100 mg once daily
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Active retinopathy. albinism. family history of hereditary retinal disease. retinal degeneration. uveitis
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Hypertension (may raise blood pressure). may exacerbate pre-existing dyskinesia (requiring levodopa dose reduction)
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→Appendix 1: MAO-B inhibitors
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▶Common or very common Cataract. dizziness. drowsiness. headache. hypotension. injury. nausea. sleep disorders ▶Uncommon Anaemia. anxiety. appetite abnormal. arrhythmias. asthenia. cognitive disorder. confusion. constipation. cough. decreased leucocytes. depression. diarrhoea. dry mouth. dysarthria. dyslipidaemia. dyspnoea. emotional lability. eye disorders. eye inflammation. gastrointestinal discomfort. gastrointestinal disorders. glaucoma. hallucination. hyperglycaemia. hypertension. increased risk of infection . joint disorders. movement disorders. muscle complaints . muscle weakness. neoplasms. oral disorders. pain. palpitations. peripheral oedema. photosensitivity reaction. psychotic disorder. QT interval prolongation. red blood cell abnormality. rhinorrhoea. sensation abnormal. sensation of pressure. sexual dysfunction. skin reactions. sweat changes. syncope. temperature sensation altered. urinary disorders. varicose veins. vertigo. vision disorders. vomiting. weight changes ▶Rare or very rare Alopecia. arterial spasm. atherosclerosis . benign prostatic hyperplasia. breast abnormalities. bronchospasm. cachexia. concentration impaired. delirium. diabetic retinopathy. dysphonia. eosinophilia. eye pain. fat embolism. fever. gambling. haemorrhage. hyperbilirubinaemia. hyperkalaemia. illusion. malaise. myocardial infarction. oropharyngeal complaints. osteoarthritis. paranoia. psychiatric disorders. pyuria. reflexes decreased. suicidal ideation. taste altered
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Manufacturer advises avoid—toxicity in animal studies.
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Manufacturer advises avoid—present in milk in animal studies.
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Manufacturer advises caution in moderate impairment (risk of increased exposure); avoid in severe impairment. Dose adjustments Manufacturer advises max. daily dose should not exceed 50 mg daily in moderate impairment.
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There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Xadago (Profile Pharma Ltd) Safinamide (as Safinamide methansulfonate) 50 mg Xadago 50mg tablets | 30 tablet P £69.00 DT = £69.00 Safinamide (as Safinamide methansulfonate) 100 mg Xadago 100mg tablets | 30 tablet P £69.00 DT = £69.00
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50 mg once daily, increased if necessary to
First-line fragment. Read the complete Indications and Dose section above.
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