Drug reference
HIV infection in combination with other antiretrovirals in patients previously treated with antiretroviral therapy— with low-dose ritonavir ▶BY MOUTH ▶Adult: 1 g every 12 hours HIV infection in combination with other antiretrovirals in patients not previously treated with antiretroviral therapy—with low-dose ritonavir ▶BY MOUTH ▶Adult: 500 mg every 12 hours for 7 days, then increased to 1 g every 12 hours
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Bradycardia. congenital QT prolongation. electrolyte disturbances. heart failure with reduced left ventricular ejection fraction. history of symptomatic arrhythmias
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→Appendix 1: HIV-protease inhibitors
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▶Common or very common Burping. constipation. dry lips. libido decreased. lipoatrophy. paraesthesia ▶Uncommon Mucosal ulceration. renal impairment. visual impairment ▶Frequency not known QT interval prolongation
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Manufacturer advises caution in moderate impairment (limited information available); avoid in decompensated liver disease.
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Use with caution if eGFR less than 30 mL/minute/1.73 m2.
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Monitor ECG before starting treatment (do not initiate treatment if QT interval over 450 milliseconds); if baseline QT interval less than 450 milliseconds, monitor ECG during treatment (particularly 10 days after starting treatment in patients not previously treated with antiretroviral therapy)— discontinue if QT interval increases over 480 milliseconds, if QT interval more than 20 milliseconds above baseline, if prolongation of PR interval, or if arrhythmias occur.
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 21 ▶Invirase (Roche Products Ltd) Saquinavir (as Saquinavir mesilate) 500 mg Invirase 500mg tablets | 120 tablet P £251.26 eiiii F 693
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Arrhythmias Patients should be told how to recognise signs of arrhythmia and advised to seek medical attention if symptoms such as palpitation or syncope develop.
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1 g every 12 hours
First-line fragment. Read the complete Indications and Dose section above.
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500 mg every 12 hours for 7 days, then increased
First-line fragment. Read the complete Indications and Dose section above.
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