Names and pronunciation
(sa-kwin′a-veer) Invirase
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Drug reference
(sa-kwin′a-veer) Invirase
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Func. class.: Antiretroviral-protease inhibitor
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USES: Treatment of HIV-1 infection in adults (>16 yr) in combination with other antiretrovirals. Saquinavir is not recommended as a component of ini- tial therapy for the treatment of HIV
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CONTRAINDICATIONS: Hyper- sensitivity or any component, congenital QT prolongation, refractory hypokale- mia/hypomagnesemia, complete AV block, use of saquinavir/ritonavir with CYP3A substrates
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DOSAGE AND ROUTES • Adult: PO 1 g bid with ritonavir 100 mg bid; for those already taking ritona- vir 100 mg bid, no additional ritonavir is needed Treatment-naive patients or pa- tients switching from a regimen containing delavirdine • Adult: PO Initial: Saquinavir 500 mg bid with ritonavir 100 mg bid × 7 days Adult: PO Maintenance: Saquinavir 1 g bid with ritonavir 100 mg bid
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Available forms: Tabs 500 mg; cap- sules 200 mg
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• Adult: PO 1 g bid with ritonavir 100 mg bid; for those already taking ritona- vir 100 mg bid, no additional ritonavir is needed Treatment-naive patients or pa- tients switching from a regimen containing delavirdine
PDF page 1191
• Adult: PO Initial: Saquinavir 500 mg bid with ritonavir 100 mg bid × 7 days Adult: PO Maintenance: Saquinavir 1 g bid with ritonavir 100 mg bid
PDF page 1191