Names and pronunciation
(sel-ih-nex′-or) Xpovio
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Drug reference
(sel-ih-nex′-or) Xpovio
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Func. class.: Antineoplastic Chem class.: Small molecule anti- neoplastic nuclear export inhibitor
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USES: Multiple myeloma in those who have received at least 4 prior therapies and who are refractory to at least 2 proteasome inhibitors, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody, in combination with dexamethasone
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CONTRAINDICATIONS Hypersensitivity, pregnancy, breastfeeding
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DOSAGE AND ROUTES •Adult: PO 80 mg in combination with dexamethasone 20 mg orally on days 1 and 3 of each week; repeat weekly until disease progression or unacceptable toxicity
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Available forms: Tablets twice-weekly blister pack 40, 60, 80 mg; once-weekly blister pack 40, 60, 80, 100 mg HIGH ALERT
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•Adult: PO 80 mg in combination with dexamethasone 20 mg orally on days 1 and 3 of each week; repeat weekly until disease progression or unacceptable toxicity
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