Drug reference

Sertraline

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 407

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Depressive illness ▶BY MOUTH ▶Adult: Initially 50 mg daily, then increased in steps of 50 mg at intervals of at least 1 week if required; maintenance 50 mg daily; maximum 200 mg per day Obsessive-compulsive disorder ▶BY MOUTH ▶Adult: Initially 50 mg daily, then increased in steps of 50 mg at intervals of at least 1 week if required; maximum 200 mg per day Panic disorder | Post-traumatic stress disorder | Social anxiety disorder ▶BY MOUTH ▶Adult: Initially 25 mg daily for 1 week, then increased to 50 mg daily, then increased in steps of 50 mg at intervals of at least 1 week if required, increase only if response is partial and if drug is tolerated; maximum 200 mg per day

PDF page 407

Safety

Interactions

→Appendix 1: SSRIs

PDF page 407

Side Effects

▶Common or very common Chest pain. depression. gastrointestinal disorders. increased risk of infection. neuromuscular dysfunction. vasodilation ▶Uncommon Back pain. burping. chills. cold sweat. dysphagia. dyspnoea. ear pain. euphoric mood. hypertension. hypothyroidism. migraine. muscle complaints. muscle weakness. oedema. oral disorders. osteoarthritis. periorbital oedema. respiratory disorders. sensation abnormal. speech disorder. thinking abnormal. thirst ▶Rare or very rare Balanoposthitis. bone disorder. cardiac disorder. coma. conversion disorder. diabetes mellitus. drug dependence. dysphonia. eye disorders. gait abnormal. genital discharge. glaucoma. hair texture abnormal. hepatic disorders. hiccups. hypercholesterolaemia. hypoglycaemia. injury. lymphadenopathy. myocardial infarction. neoplasms. oliguria. peripheral ischaemia. psychotic disorder. vasodilation procedure. vision disorders. vulvovaginal atrophy ▶Frequency not known Cerebrovascular insufﬁciency. gynaecomastia. hyperglycaemia. leucopenia. neuroleptic malignant syndrome. pancreatitis

PDF page 407

Breast Feeding

Not known to be harmful but consider discontinuing breast-feeding.

PDF page 407

Hepatic Impairment

Manufacturer advises avoid in severe impairment (no information available). Nervous system Dose adjustments Manufacturer advises dose reduction or increasing dose interval in mild to moderate impairment.

PDF page 407

Renal Impairment

Use with caution.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: tablet, oral suspension Tablet ▶Sertraline (Non-proprietary) Sertraline (as Sertraline hydrochloride) 50 mg Sertraline 50mg tablets | 28 tablet P £17.00 DT = £1.27 | 500 tablet P £12.45–£23.57 Sertraline (as Sertraline hydrochloride) 100 mg Sertraline 100mg tablets | 28 tablet P £28.00 DT = £1.55 | 500 tablet P £16.39–£27.86 ▶Lustral (Upjohn UK Ltd) Sertraline (as Sertraline hydrochloride) 50 mg Lustral 50mg tablets | 28 tablet P £17.82 DT = £1.27 Sertraline (as Sertraline hydrochloride) 100 mg Lustral 100mg tablets | 28 tablet P £29.16 DT = £1.55 ANTIDEPRESSANTS › SEROTONIN AND NORADRENALINE RE-UPTAKE INHIBITORS

PDF page 407

Clinical care

Treatment Cessation

The dose should preferably be reduced gradually over about 4 weeks, or longer if withdrawal symptoms emerge (6 months in patients who have been on long-term maintenance treatment).

PDF page 407

Patient And Carer Advice

Driving and skilled tasks Patients should be counselled on the effects on driving and skilled tasks.

PDF page 407

Dose text by age group

Adult

Initially 50 mg daily, then increased in steps of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 407

Adult

Initially 50 mg daily, then increased in steps of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 407

Adult

Initially 25 mg daily for 1 week, then increased

First-line fragment. Read the complete Indications and Dose section above.

PDF page 407

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Sertraline

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 407

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 407

Safety

Interactions

→Appendix 1: SSRIs

PDF page 407

Side Effects

PDF page 407

Breast Feeding

Not known to be harmful but consider discontinuing breast-feeding.

PDF page 407

Hepatic Impairment

PDF page 407

Renal Impairment

Use with caution.

PDF page 407

Dose and formulations

Medicinal Forms

PDF page 407

Clinical care

Treatment Cessation

The dose should preferably be reduced gradually over about 4 weeks, or longer if withdrawal symptoms emerge (6 months in patients who have been on long-term maintenance treatment).

PDF page 407

Patient And Carer Advice

Driving and skilled tasks Patients should be counselled on the effects on driving and skilled tasks.

PDF page 407

Dose text by age group

Adult

Initially 50 mg daily, then increased in steps of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 407

Adult

Initially 50 mg daily, then increased in steps of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 407

Adult

Initially 25 mg daily for 1 week, then increased

First-line fragment. Read the complete Indications and Dose section above.

PDF page 407

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.