Names and pronunciation
(se-vel′a-mer) Renagel, Renvela
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Drug reference
(se-vel′a-mer) Renagel, Renvela
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Func. class.: Phosphate binder
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USES: Control of serum phosphorous in those with chronic kidney disease on hemodialysis
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CONTRAINDICATIONS Hypersensitivity to sevelamer or any com- ponent, bowel obstruction
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DOSAGE AND ROUTES Control of serum phosphorous • Adult: PO Those not taking a phosphate binder: 800-1600 mg tid; if based on serum phosphorous levels: >5.5 mg/dL to <7.5 mg/dL: 800 mg tid; ≥7.5 mg/dL to <9 mg/dL: 1200-1600 mg tid; ≥9 mg/dL: 1600 mg tid Maintenance dose adjustment based on serum phosphorous concentration: >5.5 mg/dL: Increase by 400-800 mg per meal at 2-wk intervals; 3.5-5.5 mg/ dL: Maintain current dose; <3.5 mg/ dL: Decrease by 400-800 mg per meal Dosage adjustment when switching between phosphate-binder products: 667 mg of calcium acetate is equivalent to 800 mg sevelamer Conversion based on dose per meal: Calcium acetate 667 mg: Convert to 800 mg Renagel/Renvela; calcium ace- tate 1334 mg: Convert to 1600 mg as Renagel/Renvela (800-mg tablets × 2) or 1200 mg as Renagel (400-mg tab- lets × 3); calcium acetate 2001 mg: Convert to 2400 mg as Renagel/Renvela (800-mg tablets × 3) or 2000 mg as Renagel (400-mg tablets × 5)
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Available forms: Tabs 400, 800 mg; oral suspension 0.8, 2.4 g packets
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• Adult: PO Those not taking a phosphate binder: 800-1600 mg tid; if based on serum phosphorous levels: >5.5 mg/dL to <7.5 mg/dL: 800 mg tid; ≥7.5 mg/dL to <9 mg/dL: 1200-1600 mg tid; ≥9 mg/dL: 1600 mg tid Maintenance dose adjustment based on serum phosphorous concentration: >5.5 mg/dL: Increase by 400-800 mg per meal at 2-wk intervals; 3.5-5.5 mg/ dL: Maintain current dose; <3.5 mg/ dL: Decrease by 400-800 mg per meal Dosage adjustment when switching between phosphate-binder products: 667 mg of calcium acetate is equivalent to 800 mg sevelamer Conversion based on dose per meal: Calcium acetate 667 mg: Convert to 800 mg Renagel/Renvela; calcium ace- tate 1334 mg: Convert to 1600 mg as Renagel/Renvela (800-mg tablets × 2) or 1200 mg as Renagel (400-mg tab- lets × 3); calcium acetate 2001 mg: Convert to 2400 mg as Renagel/Renvela (800-mg tablets × 3) or 2000 mg as Renagel (400-mg tablets × 5)
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