Drug reference

Sodium chloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1123, 1124

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Prophylaxis of sodium chloride deficiency ▶BY MOUTH ▶Adult: 4–8 tablets daily, to be taken with water, up to maximum 20 tablets daily in severe depletion Chronic renal salt wasting ▶BY MOUTH ▶Adult: Up to 20 tablets daily, to be taken with appropriate ﬂuid intake Management of diabetic ketoacidosis (to restore circulating volume if systolic blood pressure is below 90 mmHg and adjusted for age, sex, and medication as appropriate) ▶BY INTRAVENOUS INFUSION ▶Adult: 500 mL, sodium chloride 0.9% to be given over 10–15 minutes, repeat if blood pressure remains below 90 mmHg and seek senior medical advice, when blood pressure is over 90 mmHg, sodium chloride 0.9% should be given by intravenous infusion at a rate that replaces deﬁcit and provides maintenance, management regimen also includes administration of potassium chloride, soluble insulin, long acting insulin analogues and glucose 10% solution Diluent for instillation of drugs to the bladder ▶BY INTRAVESICAL INSTILLATION ▶Adult: (consult product literature) Skin cleansing ▶TO THE SKIN ▶Child: Use for topical irrigation of wounds ▶Adult: Use for topical irrigation of wounds

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Cautions

▶With intravenous use Avoid excessive administration. cardiac failure. dilutional hyponatraemia especially in the elderly. hypertension. peripheral oedema. pulmonary oedema. restrict intake in impaired renal function. toxaemia of pregnancy

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Prescribing And Dispensing Information

▶With intravenous use Sodium chloride 0.9% intravenous infusion contains Na+ and Cl- each 150 mmol/litre. The term ‘normal saline’ should not be used to describe sodium chloride intravenous infusion 0.9%; the term ‘physiological saline’ is acceptable but it is preferable to give the composition (i.e. sodium chloride intravenous infusion 0.9%). ▶With oral use Each Slow Sodium ® tablet contains approximately 10 mmol each of Na+ and Cl-; g tablets can be crushed before administration l.

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Safety

Side Effects

▶With intravenous use Chills. fever. hypervolaemia. hypotension. local reaction. localised pain. paraesthesia. skin reactions. tremor. vascular irritation. venous thrombosis ▶With oral use Abdominal cramps. acidosis hyperchloraemic . diarrhoea. generalised oedema. hypertension. hypotension. irritability. muscle complaints. nausea. vomiting

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Monitoring Requirements

▶With intravenous use The jugular venous pressure should be assessed, the bases of the lungs should be examined for crepitations, and in elderly or seriously ill patients it is often helpful to monitor the right atrial (central) venous pressure.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: capsule, solution for injection, infusion, solution for infusion Modified-release tablet CAUTIONARY AND ADVISORY LABELS 25 Blood and nutrition ▶Slow Sodium (HK Pharma Ltd) Sodium chloride 600 mg Slow Sodium 600mg tablets | 100 tablet G £9.20 DT = £9.20 Solution for injection ▶Sodium chloride (Non-proprietary) Sodium chloride 9 mg per 1 ml Sodium chloride 0.9% solution for injection 50ml vials | 25 vial P £85.00–£85.01 DT = £85.01 Sodium chloride 0.9% solution for injection 10ml ampoules | 10 ampoule P £3.24–£3.70 DT = £3.24 | 20 ampoule P £10.21 | 50 ampoule P £25.50 | 100 ampoule P £51.00 Sodium chloride 0.9% solution for injection 20ml ampoules | 20 ampoule P £18.93 DT = £19.87 Sodium chloride 0.9% solution for injection 2ml ampoules | 10 ampoule P £2.33–£2.60 DT = £2.33 Sodium chloride 0.9% solution for injection 5ml ampoules | 10 ampoule P £2.50–£2.70 DT = £2.50 | 50 ampoule P £22.00 Sodium chloride 0.9% solution for injection 10ml Sure-Amp ampoules | 20 ampoule P £8.15 Sodium chloride 0.9% solution for injection 10ml Mini-Plasco ampoules | 20 ampoule P £10.21 Sodium chloride 300 mg per 1 ml Sodium chloride 30% solution for injection 10ml ampoules | 10 ampoule P £77.47 DT = £77.47 Solution for infusion ▶Sodium chloride (Non-proprietary) Sodium chloride 300 mg per 1 ml Sodium chloride 30% concentrate for solution for infusion 100ml vials | 10 vial P £59.80 DT = £59.80 Sodium chloride 30% concentrate for solution for infusion 50ml vials | 1 vial P £15.36 DT = £15.36 | 10 vial P £83.30 DT = £83.30 Sodium chloride 30% concentrate for solution for infusion 10ml ampoules | 10 ampoule P £82.70 Infusion ▶Sodium chloride (Non-proprietary) Sodium chloride 1.8 mg per 1 ml Polyfusor O sodium chloride 0.18% infusion 500ml bottles | 1 bottle P £4.18 Sodium chloride 4.5 mg per 1 ml Sodium chloride 0.45% infusion 500ml bags | 1 bag P s Polyfusor SB sodium chloride 0.45% infusion 500ml bottles | 1 bottle P £3.98 Sodium chloride 9 mg per 1 ml Sodium chloride 0.9% infusion 100ml bags | 1 bag P £0.58 Sodium chloride 0.9% infusion 250ml bags | 1 bag P s Sodium chloride 0.9% infusion 1litre bags | 1 bag P s Sodium chloride 0.9% infusion 500ml bags | 1 bag P s Sodium chloride 0.9% infusion 50ml bags | 1 bag P s Sodium chloride 0.9% infusion 100ml polyethylene bottles | 1 bottle P £0.55 | 20 bottle P £11.00 Polyfusor S sodium chloride 0.9% infusion 500ml bottles | 1 bottle P £2.84 DT = £2.84 Polyfusor S sodium chloride 0.9% infusion 1litre bottles | 1 bottle P £3.77 DT = £3.77 Sodium chloride 18 mg per 1 ml Polyfusor SC sodium chloride 1.8% infusion 500ml bottles | 1 bottle P £4.18 Sodium chloride 27 mg per 1 ml Polyfusor SD sodium chloride 2.7% infusion 500ml bottles | 1 bottle P £4.18 Sodium chloride 50 mg per 1 ml Polyfusor SE sodium chloride 5% infusion 500ml bottles | 1 bottle P £4.18 Combinations available: Potassium chloride with calcium chloride dihydrate and sodium chloride, p. 1100. Potassium chloride with calcium chloride, sodium chloride and sodium lactate, p. 1100. Potassium chloride with glucose and sodium chloride, p. 1100. Potassium chloride with sodium chloride, p. 1101

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Dose text by age group

Adult

4–8 tablets daily, to be taken with water, up to

First-line fragment. Read the complete Indications and Dose section above.

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Adult

Up to 20 tablets daily, to be taken with

First-line fragment. Read the complete Indications and Dose section above.

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Adult

500 mL, sodium chloride 0.9% to be given over

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1123

Adult

(consult product literature)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1123

Adult

Use for topical irrigation of wounds

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1123

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Sodium chloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1123, 1124

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 1123

Cautions

PDF page 1123

Prescribing And Dispensing Information

PDF pages 1123, 1124

Safety

Side Effects

PDF page 1123

Monitoring Requirements

PDF page 1123

Dose and formulations

Medicinal Forms

PDF page 1124

Dose text by age group

Adult

4–8 tablets daily, to be taken with water, up to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1123

Adult

Up to 20 tablets daily, to be taken with

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1123

Adult

500 mL, sodium chloride 0.9% to be given over

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1123

Adult

(consult product literature)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1123

Adult

Use for topical irrigation of wounds

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1123

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.