Indications And Dose
Hypertensive emergencies ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 0.5–1.5 micrograms/kg/minute, adjusted in steps of 500 nanograms/kg/minute every 5 minutes, usual dose 0.5–8 micrograms/kg/minute, use lower doses if already receiving other antihypertensives, stop if response unsatisfactory with max. dose in 10 minutes, lower initial dose of 300 nanograms/kg/minute has been used Maintenance of blood pressure at 30–40% lower than pretreatment diastolic blood pressure ▶BY INTRAVENOUS INFUSION ▶Adult: 20–400 micrograms/minute, use lower doses for patients being treated with other antihypertensives Controlled hypotension in anaesthesia during surgery ▶BY INTRAVENOUS INFUSION ▶Adult: Up to 1.5 micrograms/kg/minute Acute or chronic heart failure ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 10–15 micrograms/minute, increased every 5–10 minutes as necessary; usual dose 10–200 micrograms/minute normally for max. 3 days l UNLICENSED USE Not licensed for use in the UK.
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