Therapeutic Action
Combination of two direct-acting antivirals: a NS5B polymerase inhibitor (sofosbuvir) and a NS5A inhibitor (velpatasvir)
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Drug reference
Combination of two direct-acting antivirals: a NS5B polymerase inhibitor (sofosbuvir) and a NS5A inhibitor (velpatasvir)
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Treatment of chronic hepatitis C
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Do not administer to patients with allergy to sofosbuvir or velpatasvir. May cause: fatigue, headache, insomnia, nausea, rash. Administer with caution to patients co-infected with hepatitis B virus (risk of HBV reactivation). Do not combine with: carbamazepine, phenobarbital, phenytoin, rifampicin, rifabutin, rifapentine, efavirenz, nevirapine, etravirine (decreased sofosbuvir and/or velpatasvir plasma concentrations); amiodarone (risk of severe bradycardia and heart block) Administer with caution and monitor combination with: tenofovir, atorvastatin, digoxin (increased plasma concentration of these drugs) Do not administer simultaneously with: omeprazole: take sofosbuvir/velpatasvir 4 hours before omeprazole, with food; antacids (aluminium/magnesium hydroxide, etc.), calcium carbonate: take 4 hours apart. Closely monitor blood glucose levels in patients with diabetes (risk of hypoglycemia); adjust the antidiabetic treatment if necessary. Pregnancy and breast-feeding: CONTRA-INDICATED (safety not established)
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400 mg sofosbuvir/100 mg velpatasvir co-formulated tablet
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Genotypes 1, 2, 3, 4, 5, 6 with no cirrhosis or compensated cirrhosis Adult: one 400 mg/100 mg tablet once daily for 12 weeks Genotypes 1, 2, 3, 4, 5, 6 with decompensated cirrhosis Adult: one 400 mg/100 mg tablet once daily for 24 weeks
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Tablets have a bitter taste, they should be swallowed whole (not crushed or chewed), with meals. If the patient vomits within 3 hours after administration: take the same dose. If the patient misses a dose, the dose should be taken as soon as possible if remembered within 18 hours of the usual time. After 18 hours or more, the dose should be skipped, and the next dose taken at the usual time. Also comes in 200 mg sofosbuvir/50 mg velpatasvir co-formulated tablet for paediatric use.
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– Below 30 °C
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one 400 mg/100 mg tablet once daily for 12 weeks
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one 400 mg/100 mg tablet once daily for 24 weeks
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